Effect of transforming growth factor-beta on decorin and beta1 integrin expression during muscle development in chickens

Poultry Science
X LiS G Velleman

Abstract

Myoblast-extracellular matrix interactions play a pivotal role in skeletal muscle development. Transforming growth factor-beta (TGF-beta) is a key regulator of muscle cell proliferation and differentiation. The level of TGF-beta expressed will affect the concentration of the extracellular matrix proteoglycan decorin and the cell surface beta1 integrin subunit. The decorin proteoglycan is a regulator of cell growth as well as the organization of the extracellular matrix. The beta1 integrin plays a role in muscle cell attachment, migration, and the formation of multinucleated myotubes. In the current study, chicken myogenic satellite cells isolated from the pectoralis major muscle from the chicken genetic muscle weakness, low score normal (LSN), and normal pectoralis major muscle were used to investigate TGF-beta expression as it relates to decorin and beta1 integrin mRNA expression. The LSN muscle defect is characterized by altered myotube formation and sarcomere structure, and the satellite cells have reduced proliferation and differentiation. The mRNA expression was measured by real-time quantitative reverse transcription PCR. The LSN condition has elevated expression of TGF-beta2 and TGF-beta4 with increased expression of dec...Continue Reading

Citations

Sep 10, 2015·Animal : an International Journal of Animal Bioscience·Z G MiaoM Du
Jan 16, 2013·Cell Biology International·K Grzelkowska-KowalczykJ Tokarska
Mar 7, 2013·Journal of Animal Science·M R LapinS E Johnson
Sep 27, 2018·Annual Review of Animal Biosciences·Sandra G Velleman
Apr 21, 2017·Journal of Biomedical Materials Research. Part a·Phammela N Abarzúa-IllanesLoreto M Valenzuela
Mar 17, 2020·Experimental Eye Research·Eleanor M FeneckKeith M Meek
Aug 6, 2010·Veterinary Immunology and Immunopathology·Revathi Shanmugasundaram, Ramesh K Selvaraj
Sep 12, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Christopher M RevellKyriacos A Athanasiou
Nov 30, 2010·Biochimica Et Biophysica Acta·Alberto Fernández-Medarde, Eugenio Santos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.