Effect of transforming growth factor α overexpression on urogenital organ development in mouse

Differentiation; Research in Biological Diversity
Yuko YoshioYoshiki Sugimura

Abstract

Transforming growth factor-α (TGFα) promotes cell proliferation by binding to the epidermal growth factor receptor (EGFR). TGFα and EGFR overexpression have been reported in various human cancers. However, whether TGFα induces cancer by itself is unknown in urogenital organs. To investigate whether TGFα overexpression induces carcinogenesis in urogenital organs, we analyzed the phenotypes of urogenital organs in male TGFα transgenic (TG) mice of the CD1 strain. Urogenital organs including the kidney, bladder, prostate, seminal vesicles, testes, and epididymis were isolated from 4- to 48-week-old TGFα TG and wild-type (WT) CD1 mice. Prostates were separated into anterior prostate (AP), dorsolateral prostate (DLP), and ventral prostate (VP). Neither tumor formation nor epithelial hyperplasia was observed in the TGFα TG mouse urogenital organs that we have investigated. Histopathologically, in prostate, we found an increased number of p63-positive basal epithelial cells in the TGFα TG mice AP and DLP. There was no morphological change in the stromal component, such as hypercellular stroma or fibrosis. However, bladder weight was greater in TGFα TG mice than that in WT mice, and distended bladders were observed macroscopically in 1...Continue Reading

References

Jun 1, 1986·Biology of Reproduction·Y SugimuraA A Donjacour
Sep 1, 1993·Cancer Metastasis Reviews·K KhazaieR B Lichtner
Mar 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H S HuitfeldtP E Schwarze
Jan 1, 1996·World Journal of Urology·L S BaskinG R Cunha
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J DiGiovanniC Conti
Dec 7, 2000·The American Journal of Pathology·S SignorettiM Loda
Mar 15, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·Donatella SantiniDomenico Marrano
Sep 17, 2004·Development·Takeshi KuritaGerald R Cunha
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian ShuchIman Osman
Mar 23, 2005·Archives of Histology and Cytology·Gerald R CunhaTakeshi Kurita
May 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Barry G TimmsFrederick S vom Saal
Jun 30, 2006·Journal of Mammary Gland Biology and Neoplasia·Thorarinn GudjonssonMina J Bissell
Apr 27, 2007·Differentiation; Research in Biological Diversity·Yuji OguraYoshiki Sugimura
Aug 21, 2007·The Journal of Urology·Micah A JacobsIan C Summerhayes
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew S GoldsteinOwen N Witte
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S GordonDavid Crawford

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Citations

Apr 24, 2012·Asian Journal of Andrology·Ching-Hei YeungTrevor G Cooper
Feb 1, 2012·Gene Expression Patterns : GEP·Huizhen Wang, T Rajendra Kumar
Jun 22, 2016·Expert Opinion on Drug Metabolism & Toxicology·Florian M Wagenlehner, Jakhongir F Alidjanov
Apr 5, 2018·Journal of Clinical Medicine·Kenichiro IshiiMasatoshi Watanabe

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