PMID: 1201568Sep 1, 1975Paper

Effect of transmembrane potential on the manifestations of ouabain toxicity in sheep cardiac Purkinje fibres

Cardiovascular Research
J M GellesB F Hoffman

Abstract

The effect of membrane potential on the manifestations of ouabain-induced alterations in the electrical activity of shortened sheep cardiac Purkinje fibres was studied by a microelectrode technique. The level of membrane potential was modulated by passing intracellular polarizing current. It was found that the toxic electrical effects induced by exposure to ouabain vary according to the level of membrane potential.

Citations

May 1, 1985·Journal of the American College of Cardiology·B Surawicz
May 1, 1977·Progress in Cardiovascular Diseases·G R Ferrier
Feb 1, 1992·Pacing and Clinical Electrophysiology : PACE·J J Goldberger, R S Aronson

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