PMID: 9191505Oct 1, 1996Paper

Effect of transthoracic electric current on the coronary circulation of the dog

The Canadian Journal of Cardiology
P Macho, R Domenech

Abstract

In vitro experiments have shown that an electric field changes coronary vascular resistance (CVR) tone and damages the vascular endothelium. The effect of transthoracic electric current in dogs on the vasodilatory responses mediated through the endothelium and reactive hyperemia were studied. The manner of delivery of the electric current was similar to that used clinically during cardiac resuscitation. Eight mongrel dogs of either sex weighing between 15 and 22 kg were anesthetized with sodium pentobarbital. The lungs were mechanically ventilated and the thorax was opened. Circumflex coronary flow was measured with an electromagnetic flowmeter. Mean aortic pressure and the heart rate were kept constant and left ventricular systolic and diastolic pressures did not change during the procedures. The changes in CVR produced by different intracoronary doses of acetylcholine and reactive hyperemia to 10 and 30 s of circumflex coronary occlusion were measured before and after the transthoracic delivery of five synchronized electric shocks, 300 J each 1 min apart. CVR decreased by 32.8 +/- 2.1% (P < 0.01) from the effects of the electric shocks in spite of no changes in heart rate, ventricular systolic and diastolic pressures nor left...Continue Reading

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