PMID: 9449054Jan 1, 1997Paper

Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
S K Bhattacharya, A Kumar

Abstract

Trasina is a herbal formulation of some Indian medicinal plants classified in Ayurveda, the classic Indian system of medicine, as Medhyarasayanas or drugs reputed to improve memory and intellect. Earlier experimental and clinical investigations have indicated that the formulation has a memory-facilitating action. In this investigation, the effect of Trasina, after subchronic administration for 21 days, was assessed on two rodent models simulating some biochemical features known to be associated with Alzheimer's disease (AD). The models, in rats, included intracerebroventricularly (i.c.v.) administered colchicine (15 micrograms/rat) and lesioning of nucleus basalis magnocellularis (nbm) by ibotenic acid (10 micrograms/rat). Retention of an active avoidance response was used as the memory parameter. In addition, the effect of Trasina was evaluated on i.c.v. colchicine-induced depletion of acetylcholine (ACh) concentrations, reduction in choline acetyltransferase (ChAT) activity, and decrease in muscarinic cholinergic receptor (MCR) binding in rat brain frontal cortex and hippocampus. The behavioral and biochemical investigations were done 7, 14, and 21 days after colchicine or ibotenic acid lesioning. Trasina (200 and 500 mg/kg) ...Continue Reading

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Citations

Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·S K Bhattacharya, A V Muruganandam
Mar 21, 1998·Journal of Ethnopharmacology·G Ahmad Tajuddin
Jan 12, 1999·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·E K PerryN S Perry
Aug 5, 2011·Journal of Medicinal Food·Vijayasree Vayalanellore GiridharanTetsuya Konishi
Jul 1, 2011·Journal of Neurosciences in Rural Practice·M Obulesu, Dowlathabad Muralidhara Rao
Jan 18, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·L Pari, G Saravanan
Jun 23, 2005·BMC Complementary and Alternative Medicine·Ramalingam Saravanan, Leelavinothan Pari
Mar 3, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Pon Velayutham Anandh BabuMd Iqbal Niyas Ahamed
Jul 30, 2014·Life Sciences· NehaNirmal Singh
Jan 24, 2007·Journal of Ethnopharmacology·Nishritha Bopana, Sanjay Saxena
Jan 22, 2009·Neurobiology of Disease·Sunil Kumar HotaGovindasamy Ilavazhagan
Mar 3, 2020·Frontiers in Pharmacology·Laxman SinghAtanas G Atanasov
Jul 20, 1999·The Journal of Pharmacy and Pharmacology·E K PerryN S Perry
Nov 5, 2016·Phytotherapy Research : PTR·Seyed Fazel NabaviSeyed Mohammad Nabavi
Mar 20, 2019·Expert Review of Neurotherapeutics·Rohit SharmaP K Prajapati
Jul 18, 2020·CNS & Neurological Disorders Drug Targets·Roma GhaiGarima Kapoor

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