PMID: 11900277Mar 20, 2002Paper

Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve

International Journal of Experimental Diabetes Research
Lawrence J CoppeyMark A Yorek

Abstract

Previously we have demonstrated that diabetes causes impairment in vascular function of epineurial vessels, which precedes the slowing of motor nerve conduction velocity. Treatment of diabetic rats with aldose reductase inhibitors, aminoguanidine or myo-inositol supplementation have been shown to improve motor nerve conduction velocity and/or decreased endoneurial blood flow. However, the effect these treatments have on vascular reactivity of epineurial vessels of the sciatic nerve is unknown. In these studies we examined the effect of treating streptozotocin-induced rats with sorbinil, aminoguanidine or myo-inositol on motor nerve conduction velocity, endoneurial blood flow and endothelium-dependent vascular relaxation of arterioles that provide circulation to the region of the sciatic nerve. Treating diabetic rats with sorbinil, aminoguanidine or myo-inositol improved the reduction of endoneurial blood flow and motor nerve conduction velocity. However, only sorbinil treatment significantly improved the diabetes-induced impairment of acetylcholine-mediated vasodilation of epineurial vessels of the sciatic nerve. All three treatments were efficacious in preventing the appropriate metabolic derangements associated with either ac...Continue Reading

Citations

Mar 20, 2003·Current Diabetes Reports·Nigel A Calcutt
Nov 13, 2003·Current Diabetes Reports·Irina G Obrosova
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Shyam S Sharma, Sufyan G Sayyed
Mar 10, 2009·Pakistan Journal of Biological Sciences : PJBS·H R SameniM Makvandi
Jan 1, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Randhir SinghNavpreet Kaur
May 25, 2007·European Journal of Pharmacology·Anuj Kumar SainiShyam Sunder Sharma
Jul 23, 2005·Annals of the New York Academy of Sciences·Norman E CameronMary A Cotter
Dec 5, 2009·Phytotherapy Research : PTR·Tourandokht BaluchnejadmojaradZeynab Khastehkhodaie
Dec 9, 2008·Biochimica Et Biophysica Acta·Irina G Obrosova
Mar 14, 2018·Journal of Diabetes Investigation·Masaki Kobayashi, Douglas W Zochodne
May 25, 2018·Medicinal Chemistry·Qi HuangDongsheng Ouyang
Jun 11, 2019·Metabolomics : Official Journal of the Metabolomic Society·Marina Mora-OrtizSandrine P Claus
Mar 20, 2019·Diabetes/metabolism Research and Reviews·Gloria FormosoAgostino Consoli
Dec 8, 2020·Critical Reviews in Food Science and Nutrition·Oliver C WatkinsShiao-Yng Chan
May 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrick Kwabena OduroQilong Wang
Aug 22, 2021·Antioxidants & Redox Signaling·Eftekhar Eftekharpour, Paul Fernyhough
Apr 3, 2010·Biochemical Pharmacology·Chun-Hong ShaoKeshore R Bidasee

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