Effect of triclosan on the formation of crystalline biofilms by mixed communities of urinary tract pathogens on urinary catheters

Journal of Medical Microbiology
Gareth J Williams, David J Stickler

Abstract

The crystalline bacterial biofilms that encrust Foley catheters compromise the care of many elderly and disabled patients. The aim of this study was to examine whether the biocide triclosan can prevent encrustation by the mixed flora of uropathogens that commonly infect patients undergoing long-term catheterization. Models of the catheterized bladder were inoculated with communities of organisms isolated from patients who were experiencing catheter blockage. The catheter retention balloons were inflated with water or triclosan (3 g triclosan l(-1) in 0.1 M sodium carbonate) and urine was supplied to the models for up to 7 days. The effect of triclosan was recorded on the viable cell populations, the pH of the residual urine and the times that catheters took to block. The extent of encrustation of the catheters was visualized by scanning electron microscopy. In models inoculated with communities containing Proteus mirabilis, triclosan prevented the rise in urinary pH that drives crystalline biofilm formation and catheter blockage. The biocide had no effect on populations of Enterococcus faecalis and Pseudomonas aeruginosa, but Proteus mirabilis, Escherichia coli and Klebsiella pneumoniae were eliminated from the residual urine a...Continue Reading

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Citations

Apr 18, 2012·Nature Reviews. Urology·Danish M Siddiq, Rabih O Darouiche
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Rosa Capita, Carlos Alonso-Calleja
Sep 19, 2015·Journal of Medical Engineering & Technology·Roger C L FeneleyPeter N T Wells
Oct 27, 2015·Journal of Medical Microbiology·Shamlan M S ReshamwalaSantosh B Noronha
Jan 25, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven M JonesJennifer M Macrae
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Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brinta BhattacharjeeJayanta Haldar

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