PMID: 9544776Apr 17, 1998Paper

Effect of trifluoperazine on in vitro ATP synthesis by Mycobacterium leprae

FEMS Immunology and Medical Microbiology
Vishwa Mohan KatochP S Murthy

Abstract

The effect of trifluoperazine (TFP), a calmodulin antagonist, was investigated on in vitro ATP levels of human derived Mycobacterium leprae. M. leprae were obtained from biopsies from multi-bacillary forms of leprosy and were incubated in a modified Dubos medium system which supports limited in vitro synthesis of M. leprae. This incubation was carried out in the absence and presence of different concentrations of trifluoperazine. Samples for estimation of bacillary ATP levels were taken at day 0 and at 14 days of incubation. TFP inhibited ATP levels in M. leprae and this inhibitory effect was marginal at 2.5 microg ml(-1) (35% inhibition), highly significant at 5 microg ml(-1) (87% inhibition) and almost total at 10 microg ml(-1) (98.5% inhibition). This compound appears to have potential as an anti-leprotic drug and also as a broad spectrum anti-mycobacterial agent in view of its anti-tubercular activity reported earlier.

References

Feb 28, 1985·Biochemical and Biophysical Research Communications·A C HarmonM J Cormier
Jan 14, 1986·Biochemical and Biophysical Research Communications·I J FryJ H Hageman
May 1, 1987·Antimicrobial Agents and Chemotherapy·S G Franzblau, R C Hastings
Sep 3, 1987·Nature·D G SwanP F Leadlay
Feb 12, 1981·Biochemical and Biophysical Research Communications·Y IwasaE Miyamoto
Mar 1, 1995·International Clinical Psychopharmacology·P RatnakarP S Murthy

❮ Previous
Next ❯

Citations

Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Edward A WeinsteinHarvey Rubin
May 1, 2008·Expert Review of Vaccines·Lynn G DoverGurdyal S Besra
May 6, 2017·Expert Opinion on Therapeutic Targets·Satheeshkumar SellamuthuSushil Kumar Singh
Sep 4, 2007·British Journal of Clinical Pharmacology·H K R Thanacoody
Feb 24, 2018·Pathogens·Iram Khan IqbalAshwani Kumar
Jan 29, 2021·Frontiers in Cellular and Infection Microbiology·Erik J HasenoehrlMichael Berney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.