PMID: 6882908Aug 1, 1983

Effect of triftazin and haloperidol on the activity of phenazepam

Biulleten' eksperimental'noĭ biologii i meditsiny
G M Molodavkin, S G Belousova

Abstract

The effects of trifluoperazine and haloperidol on protective activity of phenazepam were studied during seizures in mice treated with pentylenetetrazole (an index used for the appraisal of tranquilizing activity) as was their action on the phenazepam-induced depression of the test potential in the recovery cycles of somatosensory primary response. Trifluoperazine administered in doses of 0.1-0.5 mg/kg potentiated anticonvulsant action of phenazepam but did not change its effects on the recovery cycles of primary response. Haloperidol also potentiated anticonvulsant action of phenazepam. However, the doses administered were 4-5-fold lower than the tranquilizing doses of haloperidol. The drug also increased the depression of the test potential in the somatosensory recovery cycle, caused by phenazepam. This suggests an increment of GABA-positive effect of the tranquilizer. It appears that higher activity of haloperidol in elevating anticonvulsant and, probably, anxiolytic effects of phenazepam is determined by interaction of these drugs on the level of cortical GABA-ergic receptors.

References

Jun 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·V G Zin'kovskiĭS A Andronati
Jan 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·G N Kryzhanovskiĭ, M N Aliev
Aug 1, 1975·Biulleten' eksperimental'noĭ biologii i meditsiny·R M Salimov

Related Concepts

Phenazepam, 2-(14)C-labeled cpd
Anticonvulsants
Benzodiazepines
Benzodiazepinones
Drug Augmentation
Polychemotherapy
Potentials, Event-Related
Haldol
Non-epileptic Convulsion
Somatosensory Cortex

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