Effect of triiodothyronine augmentation on rat lung surfactant phospholipids during sepsis

Journal of Applied Physiology
S M KsenzenkoS A Dulchavsky

Abstract

Surfactant functional effectiveness is dependent on phospholipid compositional integrity; sepsis decreases this through an undefined mechanism. Sepsis-induced hypothyroidism is commensurate and may be related. This study examines the effect of 3,3',5-triiodo-L-thyronine (T3) supplementation on surfactant composition and function during sepsis. Male Sprague-Dawley rats underwent sham laparotomy (Sham) or cecal ligation and puncture (CLP) with or without T3 supplementation [CLP/T3 (3 ng/h)]. After 6, 12, or 24 h, surfactant was obtained by lavage. Function was assessed by a pulsating bubble surfactometer and in vivo compliance studies. Sepsis produced a decrease in surfactant phosphatidylglycerol and phosphatidic acid, with an increase in lesser surface-active lipids phosphatidylserine and phosphatidylinositol. Phosphatidylcholine content was not significantly changed. Sepsis caused an alteration in the fatty acid composition and an increase in saturation in most phospholipids. Hormonal replacement attenuated these changes. Lung compliance and surfactant adsorption were reduced by sepsis and maintained by T3 treatment. Thyroid hormone may have an active role in lung functional preservation through maintenance of surfactant homeos...Continue Reading

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Citations

Apr 22, 2017·Current Allergy and Asthma Reports·Divyaanka IyerAnurag Agrawal
Sep 1, 2015·Immunologic Research·Helena M LingeEdmund J Miller
Nov 29, 2012·The Journal of Trauma and Acute Care Surgery·S Rob ToddFrederick A Moore
Jun 13, 2015·Antioxidants & Redox Signaling·Kiichi NakahiraAugustine M K Choi
May 22, 2018·Frontiers in Immunology·Serge Grazioli, Jérôme Pugin
Jun 5, 2020·Lipids in Health and Disease·Christina W AgudeloItsaso Garcia-Arcos
May 21, 2020·Frontiers in Pediatrics·Stephanie CoqueletJean-Michel Hascoët

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