PMID: 6165962May 1, 1981Paper

Effect of triiodothyronine on renal growth and renal sodium reabsorption in hypothyroid rats

Pflügers Archiv : European journal of physiology
C S LoT N Lo

Abstract

Experiments were carried out to compare temporal changes in the paraaminohippuric acid clearance (CPAH), renal sodium reabsorption (RNa+), ribonucleic acid (RNA), and deoxyribonucleic acid (DNA) content in hypothyroid rats after a single injection of triiodothyronine (T3) (50 micrograms/100 g body wt). CPAH and RNa+ showed no changes at 24 and 48 h. At 72 h, however, significant increases of 41% and 42% (per g kidney wet wt) were observed in CPAH and RNa+, respectively. The cortex in T3-treated hypothyroid rats showed a significant increase in the protein/DNA and RNA/DNA ratios at 24 h and progressive increases to a level of 24%, and 37%, respectively, at 48 h. No changes in DNA content were observed at either time-points. The results show that the increases in RNA/DNA and protein/DNA ratios upon T3 treatment preceded the increases in CPAH and RNa+, suggesting a direct effect of T3 on renal cortical growth, rather than a secondary response to a primary increase in renal functions.

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Citations

Oct 1, 1986·Pflügers Archiv : European journal of physiology·C Barlet, A Doucet
Sep 26, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mehmet BülbülTayfur Giniş
Aug 1, 2012·Pakistan Journal of Biological Sciences : PJBS·Azad Reza Mansourian
Oct 1, 1987·Kidney International·G CapassoR Kinne

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