Effect of triiodothyronine on the muscarinic receptors and acetylcholinesterase activity of developing rat brain

The International Journal of Neuroscience
G N MoskovkinF Hajós

Abstract

The effect of triiodothyronine was investigated on the developing muscarinic system in rat cerebral cortex. Triiodothyronine was administered from birth to day 30. In the synaptosomal membrane fraction of the cerebral cortex, acetylcholinesterase activity and the binding of the muscarinic ligand 3H-quinuclidinyl-benzylate increased significantly as compared to the control. An analysis of the binding curve based on Hill plots suggested a positive cooperativity of receptors of the membrane samples obtained from both hormone treated and control animals. The results obtained are in accordance with morphological, biochemical and clinical data on the thyroid hormone effect on central nervous system maturation.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R G Siman, W L Klein
Feb 23, 1979·Brain Research·A Ruiz-MarcosG Morreale de Escobar
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Jan 1, 1969·Annual Review of Pharmacology·D R Curtis, J M Crawford
Jun 1, 1974·British Journal of Pharmacology·A S BurgenJ M Young
Jan 1, 1984·International Review of Neurobiology·M Sokolovsky
Feb 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J Kastrup, N J Christensen
Jan 28, 1982·Brain Research·H Repke, K Maderspach
Aug 1, 1982·Journal of Neurochemistry·J E TaylorE Richelson
Nov 1, 1981·Journal of Neurochemistry·R G Siman, W L Klein
Jan 1, 1955·Acta Anatomica·J T EAYRS
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·O M Almeida, R Santos
Apr 24, 1992·Brain Research. Developmental Brain Research·A GiguèreD Bellabarba

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