Effect of trimethoprim on the occurrence of drug-resistant coliform bacteria in the faecal flora

Chemotherapy
A ToivanenP Toivanen

Abstract

The occurrence of drug-resistant coliform bacteria was studied in the faecal flora of 30 persons receiving for 3 weeks either trimethoprim alone, a combination of sulphamethoxazole and trimethoprim, or a combination of sulphamethoxydiazine and sulphamethoxazole. Bacterial sensitivity was tested against trimethoprim, sulphamethoxazole-trimethoprim, sulphamethoxazole, and sulphaisodimidine. After treatment with trimethoprim alone, no increase in the occurrence of strains resistant to either trimethoprim or sulphonamides was observed. After treatment with sulphamethoxazole-trimethoprim, the faecal flora contained an increased percentage of sulphonamide-resistant coliforms but significantly less than found after treatment with sulphamethoxydiazine-sulphamethoxazole. In the persons receiving the sulphonamides only, a rapid increase in sulphonamide-resistant coliforms was observed. During the whole study, only one trimethoprim-resistant coliform strain was detected.

Citations

Jan 1, 1981·Antimicrobial Agents and Chemotherapy·R L GuerrantR H Hodge
Aug 1, 1985·Antimicrobial Agents and Chemotherapy·P HuovinenP Toivanen
Jan 12, 1980·British Medical Journal·P Huovinen, P Toivanen
Aug 30, 1980·British Medical Journal
Jul 22, 1978·Lancet·W Brumfitt, J M Hamilton-Miller
May 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M CastelliI Galatulas

Related Concepts

Teens
Drug Combinations
Antibiotic Resistance, Microbial
Paracolobactrum
Feces
Sulfameter
Gantanol
Sulfanilamides
Trimpex

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