PMID: 6165809Apr 1, 1981Paper

Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid

Journal of Neurology, Neurosurgery, and Psychiatry
S N Young, S Gauthier

Abstract

Tryptophan 5-hydroxyindoleacetic acid and indoleacetic acid were measured in cerebrospinal fluid taken during pneumoencephalography from patients, some of whom took a 3 g or 6 g tryptophan load at various times before. Measurements were made on both lumbar and cisternal cerebrospinal fluid and the results showed similarities between indoleamine metabolism in human brain and spinal cord. Our data suggested that (1) the blood-brain barrier active transport system for tryptophan is not far from saturation with tryptophan and the rate-limiting enzyme in 5-hydroxytryptamine (5HT) synthesis, tryptophan hydroxylase, is about half saturated. Therefore, both 3 g and 6 g tryptophan loads produced the same maximum rise in 5HT synthesis of just under 100%, (2) tryptamine differs from 5HT in two respects. It is more sensitive to changes in tryptophan availability than 5HT and the 6 g load increased brain tryptamine metabolism more than the 3 g load; also some of the tryptamine in brain is derived from peripheral sources and diffuses from blood to brain, (3) although the brain tryptamine content is much lower than that of 5HT, its rate of metabolism as indicated by CSF metabolite levels is not. In controls the rate of tryptamine metabolism i...Continue Reading

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Citations

Jan 1, 1985·Psychopharmacology·S N YoungF R Ervin
Mar 1, 1996·Amino Acids·E L SainioS N Young
Jan 1, 1994·Journal of Neural Transmission. General Section·C J Clayton, R E Hicks
Mar 23, 2007·Psychopharmacology·Donald M DoughertyAbdulla A-B Badawy
Jul 20, 2011·Psychopharmacology·Oliver J RobinsonBarbara J Sahakian
Jun 12, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dingyan ChenZengzhen Wang
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·B ChamberlainS N Young
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·K B FranklinS N Young
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·S N Young
Aug 1, 1989·Psychiatry Research·I M AndersonP J Cowen
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S N Young, K L Teff
Nov 20, 2002·Biological Psychiatry·Justine M KentJack M Gorman
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Simon N Young, Marco Leyton
Jan 1, 1997·Clinical Psychology Review·M E BermanE F Coccaro
Mar 31, 1999·Psychoneuroendocrinology·A V RavindranH Anisman
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A AgazziM Tonini
Nov 1, 1990·Psychological Medicine·I M AndersonP J Cowen
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Rob Markus, Christine Firk
Jul 16, 2009·Nature Reviews. Neuroscience·Walter H KayeMartin Paulus
Oct 2, 2001·Journal of Neurochemistry·M Diksic, S N Young
Sep 25, 2003·The Journal of Nervous and Mental Disease·Yechiel LevkovitzEttie Grauer
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon N Young
Nov 5, 2011·Medicine and Science in Sports and Exercise·Michel O MelanconIsabelle J Dionne
Feb 23, 2013·Journal of Psychiatry & Neuroscience : JPN·Simon N Young
May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Mijanur RahmanMd Ibrahim Khalil
Mar 8, 2013·Future Microbiology·Steven E Fiester, Luis A Actis
Feb 11, 2014·BMC Psychiatry·Beata KonarzewskaLucyna Ostrowska
Aug 12, 2014·Pathologie-biologie·M O MelanconI J Dionne
Jan 12, 2013·Neurochemistry International·Faisal ShabbirSushil Sharma
Apr 7, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Christine Firk, C Rob Markus
Jan 1, 2008·Physiology & Behavior·Walter Kaye
Mar 26, 2003·The International Journal of Eating Disorders·Walter H KayeAnita Kishore
Jul 25, 2008·Journal of Cellular Physiology·Catherine Jonnakuty, Claudia Gragnoli
Apr 26, 2012·The International Journal of Eating Disorders·Guido K W Frank, Walter H Kaye
Apr 15, 2011·Acta Psychiatrica Scandinavica·G Parker, H Brotchie
Jan 24, 2007·Biological Psychiatry·Ursula F BailerWalter H Kaye
Nov 20, 1989·Brain Research·S C CheethamG P Reynolds

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