PMID: 9161884Mar 1, 1997Paper

Effect of TSH and anti-TSH receptor antibodies on the plasma membrane potential of polymorphonuclear granulocytes

Immunology Letters
E KissJ Matkó

Abstract

Effects of thyrotropin hormone (TSH) and anti-TSH receptor antibodies on the plasma membrane potential of polymorphonuclear granulocytes (PMN) were analyzed by means of flow cytometry. Both TSH and the autoantibody caused a rapid, dose-dependent hyperpolarization of the plasma membrane of PMNs. TSH was also able to mask (revert) the depolarizing effect of a chemotactic peptide, fMLP, on PMNs. No detectable rise in the cytosolic free calcium level accompanied the observed hyperpolarization. Quinine, a blocker of Ca(2+)-activated and voltage-gated K+ channels did not affect the hyperpolarization by TSH and antibodies. Decreasing the [K+] gradient across the plasma membrane by valinomycin, however, blocked the hyperpolarizing effect. Peptide362-376 (derived from the extracellular domain of TSH receptor) also blocked the hyperpolarization induced by both TSH and anti-TSHR antibodies. These data suggest that the observed hyperpolarization is a specific, receptor-mediated early signal during interaction of PMNs with TSH or anti-TSHR antibodies.

References

Mar 1, 1977·Molecular and Cellular Endocrinology·O Chabaud, S Lissitzky
Jun 1, 1992·Journal of Endocrinological Investigation·C BalázsE Kiss
Jul 1, 1990·Journal of Clinical Immunology·J P CoutelierB S Prabhakar
Jan 1, 1985·The Journal of Physiology·M D CahalanS Gupta
Feb 1, 1988·Endocrine Reviews·B Rees SmithJ Furmaniak
Jan 1, 1983·European Journal of Immunology·M N IslamN R Farid
Mar 15, 1993·Biochemical and Biophysical Research Communications·J MatkóS Damjanovich

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Citations

May 28, 2003·Journal of Cellular and Molecular Medicine·Alexandra LivescuDana Iordachescu
Apr 4, 2019·The Journal of Experimental Medicine·Chongbo YangJiajun Zhao
Feb 10, 2017·International Journal of Dermatology·Maria R C SilvaresGláucia M F da S Mazeto
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stepan S BasokMark T Quinn

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