Effect of Tualang honey on the anastomotic wound healing in large bowel anastomosis in rats-A randomized controlled trial

BMC Complementary and Alternative Medicine
Muhammad Izani AznanAndee Dzulkarnaen Zakaria

Abstract

Honey has long been used for the treatment of number of ailments and diseases including surgical wounds. Current study evaluates the effectiveness of Tualang honey (TH) for large bowel anastomotic healing in Wistar rats. Thirty male Wistar rats were given a 3 centimeter infra-umbilical laparotomy wound, in`flicted on their abdomen. The colonic transection was performed at 5 cm distal to caecum, with end to end anastomosis of colon segment. They were divided into two groups. Group I was fed with standard rat chow and water. Meanwhile, Group II apart from standard feed, was also given TH 1.0 g/kg every morning until day seven post operatively. Afterwards, anastomotic bursting pressures were measured and histopathological examination on the anastomosis line was performed with light microscopes. The data from two groups were analyzed by Independent paired t test for continuous variables. It was found that the tensile strength of colon anastomosis (95 % CI; p = <0.001) and the histopathological study including fibroblast count (p = <0.001) and inflammatory cells (p = 0.002) showed statistically significant difference in the favor of TH-treated group. Meanwhile, neovascularization formation was not statistically significant (p = 0.80...Continue Reading

References

Sep 1, 1996·Burns : Journal of the International Society for Burn Injuries·M Subrahmanyam
Aug 1, 1997·Journal of the American College of Surgeons·A VignaliJ R Oakley
Feb 3, 1999·The Journal of Surgical Research·P A Jimenez, M A Rampy
Jun 22, 2001·Journal of the Royal Society of Medicine·H Ellis
Jan 25, 2007·Annals of Surgery·Neil HymanPeter A Cataldo
Nov 24, 2007·International Journal of Colorectal Disease·Nicolas C BuchsPhilippe Morel
Dec 20, 2007·International Journal of Surgery·Ahmet AslanElif Canbolant
Feb 19, 2008·Journal of Pediatric Surgery·Mine Fedakar-SenyucelHuseyin Dindar
Aug 13, 2008·Phytotherapy Research : PTR·Avni GolluMehmet Ali Akkus
Aug 23, 2008·World Journal of Gastroenterology : WJG·Sibel Serin KilicogluEsra Erdemli
Aug 30, 2008·World Journal of Gastroenterology : WJG·Ronan A Cahill, H Paul Redmond
Sep 17, 2008·Archives of Surgery·Paul SudingSamuel Eric Wilson
Jun 26, 2010·BMC Complementary and Alternative Medicine·Nur-Azida Mohd NasirMehru-Nisha Muhammad Haneef
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Mahaneem MohamedSiti Amrah Sulaiman
Aug 24, 2011·Journal of Medicinal Food·Noori S Al-WailiAhmad A Al Ghamdi

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Citations

Jan 29, 2019·Advances in Pharmacological Sciences·Fatin Aina Zulkhairi AminNorhasnida Zawawi
Feb 6, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Yanwei SunYibing Wang

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PS
Statistical Package for the Social Science ( SPSS )

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