Effect of tumor burden and route of administration on the immunotherapeutic properties of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethyl cellulose [Poly(I,C)-LC

International Journal of Immunopharmacology
P L BlackJ E Talmadge

Abstract

We examined the immunomodulatory and therapeutic activities of poly(I,C)-LC. Mice received a subcutaneous (s.c.) injection of sufficient numbers of MBL-2 lymphoma cells to produce in 1 week either a high or low tumor burden. A week after tumor cell injection, poly(I,C)-LC treatment was initiated; the agent was administered intraperitoneally (i.p.) at 5 mg/kg twice a week or at 2.5 or 0.5 mg/kg every day or as an intravenous (i.v.) injection at 0.5, 0.05, or 0.005 mg/kg three times a week. Poly(I,C)-LC treatment significantly increased antitumor effector cell functions in a variety of organs (including spleen, lungs, and peritoneum), as shown by increased killing of MBL-2 cells in vitro and increased tumor cell killing by natural killer cells and macrophages. Furthermore, prolongation of survival correlated with peritoneal macrophage tumoricidal activity when poly(I,C)-LC was given i.p. and with pulmonary effector cell function (including natural killer, cytolytic T-lymphocyte and macrophage tumoricidal activity) when the agent was administered i.v.

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Citations

Dec 1, 2009·Neurosurgery Clinics of North America·Nicholas Butowski
Nov 25, 2015·Immunotherapy·Anda-Alexandra CalinescuMaria Graciela Castro
Aug 29, 1997·Journal of Toxicology and Environmental Health·M D CohenJ T Zelikoff
Jan 16, 2021·The Urologic Clinics of North America·Andres M Salazar, Esteban Celis
Feb 23, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Emily De LombaerdeBruno G De Geest

Related Concepts

Poly ICLC, sodium salt
Metazoa
Cethylose
Injections, Intraperitoneal
Intravenous Injections
Natural Killer Cells
Macrophage
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasms, Experimental

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