Effect of two antiprogestins (mifepristone and onapristone) on endometrial factors of potential importance for implantation

Fertility and Sterility
S T CameronD T Baird

Abstract

To investigate the effects of postovulatory administration of antiprogestins on endometrial factors that may be of importance for successful implantation. Ten women were given 200 mg mifepristone and an additional 10 women 400 mg of onapristone 48 hours after the LH surge in urine (LH + 2). Biopsies were assessed for histologic dating and the immunolocalization of [1] leukemia inhibitory factor, [2] 15-hydroxyprostaglandin dehydrogenase, and [3] the cell proliferation marker Ki 67. Hormonal measurements in blood and urine were used to monitor the effects on the ovarian cycle. Glycodelin (placental protein 14) concentrations were measured in blood taken on LH + 12. Treatment with antiprogestins retarded the development of secretory changes without affecting the length of the luteal phase. In addition, there was reduced immunostaining for 15-hydroxyprostaglandin dehydrogenase within glands and a significant reduction in serum levels of glycodelin. Reduced immunostaining for leukemia inhibitory factor also was apparent within glands in biopsies taken on LH + 6 of the treatment cycle. Increased Ki 67 immunostaining was observed on both cycle days after treatment, consistent with P antagonism. Administration of mifepristone and onap...Continue Reading

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Citations

Dec 12, 2003·Steroids·Hilary O D CritchleyDavid T Baird
Dec 12, 2003·Steroids·David T BairdAlistair R W Williams
Dec 31, 2003·Contraception·Kristina Gemzell-DanielssonLena Marions
Dec 31, 2003·Contraception·Horacio B Croxatto
Apr 9, 1998·Fertility and Sterility·A S PoddarS Parthasarathy
Nov 7, 1998·Fertility and Sterility·L MarionsM Bygdeman
Dec 12, 2003·Steroids·Kristina Gemzell DanielssonMarc Bygdeman
Nov 4, 2000·Biochimica Et Biophysica Acta·M HalttunenH Koistinen
Feb 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L G NardoF Nardo
Jul 5, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I R HorowitzS Ramachandran
Dec 7, 2013·Human Reproduction Update·Sarah E MelfordJustin C Konje
Dec 18, 2013·Progress in Biophysics and Molecular Biology·Jayasree Sengupta, Debabrata Ghosh
Jan 18, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·P Hanifi-MoghaddamL J Blok
Nov 2, 2012·Contraception·Kristina Gemzell-DanielssonLalitkumar P G L
Dec 17, 2008·Women's Health·Sophie OuzounianNathalie Chabbert-Buffet
Aug 15, 2008·Human Reproduction Update·Scott M Nelson, Ian A Greer
Oct 12, 2010·Contraception·Kristina Gemzell-Danielsson
Dec 7, 2007·Fertility and Sterility·Bunyamin BorekciSedat Kadanali
Mar 15, 2005·Acta Obstetricia Et Gynecologica Scandinavica·N N Sarkar
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