PMID: 7371695Jan 1, 1980Paper

Effect of two antiserotoninergic drugs, methysergide and metergoline, on gastric acid secretion and gastrin release in healthy man

European Journal of Clinical Pharmacology
R CaldaraP Telloli

Abstract

The effects of acute oral administration of the antiserotoninergic drugs methysergide (3 mg) and metergoline (4 mg) on basal, submaximal (0.6 micrograms/kg i. m.) and maximal (6 micrograms/kg) pentagastrin-stimulated gastric acid secretion, as well as on basal and food-induced gastrin release, have been evaluated in healthy volunteers. Methysergide significantly increased basal and submaximal pentagastrin-stimulated gastric acid secretion, and metergoline significantly inhibited gastric acidity in all experiments. Basal and stimulated serum gastrin concentrations were not modified by either drug. The effect of methysergide on gastric acid secretion was opposed to that of serotonin and was probably dependent on its antiserotoninergic action, but the decrease in gastric acidity caused by metergoline is not easily explained. Although the effect is similar to that of a dopamine infusion, it does not depend on dopamine infusion, it does not depend on dopamine receptor stimulation, since it was not influenced by pretreatment with metoclopramide. It is suggested that it might be due to the weak anticholinergic and/or antihistaminic properties of metergoline.

References

Dec 1, 1977·Life Sciences·E E MůllerP Mantegazza
Aug 1, 1976·The Journal of Clinical Endocrinology and Metabolism·P G ChiodiniF Silvestrini
Sep 1, 1965·The Journal of Pharmacy and Pharmacology·S ConsoloL Valzelli
Dec 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·J M BerkowitzI F Miller
Jan 23, 1971·British Medical Journal·J H Baron, J A Williams
Jan 1, 1965·The Journal of Pharmacy and Pharmacology·S CONSOLOL VALZELLI

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Citations

Nov 28, 2013·Acta Physiologica·H L WaldumR Fossmark
Jan 1, 1983·British Journal of Pharmacology·S P Canfield, J E Spencer

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