Effect of two carbohydrate-modified tube-feeding formulas on metabolic responses in patients with type 2 diabetes

Nutrition
Anne Coble VossVikkie A Mustad

Abstract

This study evaluated the glycemic, insulinemic, and glucagon-like peptide-1 (GLP-1) responses of subjects with type 2 diabetes mellitus to consumption of two diabetes-specific tube-feeding formulas (slowly digested carbohydrate formula [SDC] and diabetes-specific formula [DSF]) and one formula intended for individuals without diabetes (standard formula [STND]). Forty-eight subjects controlled with diet and/or oral antihyperglycemic medications received the SDC, DSF, and STND. Postprandial glucose, insulin, and GLP-1 were measured on three occasions after an overnight fast in a double-blinded, randomized, three-treatment, crossover design. The positive area under the curve for glucose and insulin with the STND was higher (P < 0.001) compared with the SDC and DSF. The adjusted GLP-1 concentration at 60 min was higher for the SDC compared with the DSF and STND (P < 0.05). Both lower-carbohydrate diabetes-specific formulas resulted in a lower postprandial blood glucose response compared with the STND. The formula also rich in slowly digested carbohydrate and monounsaturated and omega-3 fatty acids (SDC) produced significantly lower blood glucose and insulin responses and higher levels of GLP-1 in the presence of significantly lower...Continue Reading

References

Mar 1, 1995·The Journal of Endocrinology·S WakabayashiA Matsuoka
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Dec 8, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·E MannucciC M Rotella
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Sep 27, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·H ConnorUNKNOWN Nutrition Subcommittee of the Diabetes Care Advisory Committee of Diabetes UK
Jan 30, 2004·Diabetes Care·Stephen ClementUNKNOWN American Diabetes Association Diabetes in Hospitals Writing Committee
Aug 19, 2004·Diabetes Research and Clinical Practice·Pratik Choudhary
Mar 1, 2005·Metabolism: Clinical and Experimental·Werner KernBernd Schultes
May 10, 2005·The British Journal of Nutrition·Nathalie M DelzenneAudrey M Neyrinck
Nov 18, 2005·Lancet·Vincent Falanga
Mar 7, 2006·Cell Metabolism·Daniel J Drucker

❮ Previous
Next ❯

Citations

Dec 21, 2010·Current Diabetes Reports·Michael A Via, Jeffrey I Mechanick
May 18, 2010·Diabetes Technology & Therapeutics·Carolyn J AlishVikkie A Mustad
Oct 13, 2009·Nutrition·Alaa Al-KhalifaHussein M Dashti
Aug 24, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Cynthia Hamilton, Victoria J Boyce
Apr 23, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Roland N DickersonRex O Brown
Jul 13, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Yuan ShaoGang Hu
Feb 7, 2020·Nutrients·Vikkie A MustadRicardo Rueda
Feb 25, 2017·Journal of Strength and Conditioning Research·Megan M HetrickRobert R Kraemer
Nov 10, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alfonso MesejoFátima Martinez-Lozano
Jul 28, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Vishal Nainesh PatelHelen L MacLaughlin
Jan 29, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Yatin MehtaSameer Rao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.