Abstract
This study evaluated the glycemic, insulinemic, and glucagon-like peptide-1 (GLP-1) responses of subjects with type 2 diabetes mellitus to consumption of two diabetes-specific tube-feeding formulas (slowly digested carbohydrate formula [SDC] and diabetes-specific formula [DSF]) and one formula intended for individuals without diabetes (standard formula [STND]). Forty-eight subjects controlled with diet and/or oral antihyperglycemic medications received the SDC, DSF, and STND. Postprandial glucose, insulin, and GLP-1 were measured on three occasions after an overnight fast in a double-blinded, randomized, three-treatment, crossover design. The positive area under the curve for glucose and insulin with the STND was higher (P < 0.001) compared with the SDC and DSF. The adjusted GLP-1 concentration at 60 min was higher for the SDC compared with the DSF and STND (P < 0.05). Both lower-carbohydrate diabetes-specific formulas resulted in a lower postprandial blood glucose response compared with the STND. The formula also rich in slowly digested carbohydrate and monounsaturated and omega-3 fatty acids (SDC) produced significantly lower blood glucose and insulin responses and higher levels of GLP-1 in the presence of significantly lower...Continue Reading
References
Jul 1, 1990·Diabetes Care·M L WheelerN Fineberg
Mar 1, 1983·The Journal of Pediatrics·R SidebottomR T Bramson
Jul 1, 1995·Diabetes Care·T M WoleverD J Jenkins
Mar 1, 1995·The Journal of Endocrinology·S WakabayashiA Matsuoka
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Dec 24, 1997·Diabetes Care·A AvignonL Monnier
Jul 1, 1998·Nutrition·L D CraigR D Kennedy
Apr 4, 2000·European Journal of Clinical Nutrition
Dec 8, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·E MannucciC M Rotella
Feb 22, 2001·Endocrinology·A S RoccaP L Brubaker
Nov 19, 2002·Diabetologia·C BeysenK N Frayn
Dec 28, 2002·Diabetes·Alexandra E ButlerPeter C Butler
Mar 1, 2003·Diabetes Care·Shaista QuddusiDavid A D'Alessio
Sep 27, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·H ConnorUNKNOWN Nutrition Subcommittee of the Diabetes Care Advisory Committee of Diabetes UK
Jan 30, 2004·Diabetes Care·Stephen ClementUNKNOWN American Diabetes Association Diabetes in Hospitals Writing Committee
Aug 19, 2004·Diabetes Research and Clinical Practice·Pratik Choudhary
Dec 30, 2004·Diabetologia·S G WestP M Kris-Etherton
Mar 1, 2005·Metabolism: Clinical and Experimental·Werner KernBernd Schultes
May 10, 2005·The British Journal of Nutrition·Nathalie M DelzenneAudrey M Neyrinck
Jun 25, 2005·Obesity Research·Patrice D CaniNathalie M Delzenne
Aug 4, 2005·European Journal of Clinical Nutrition·M PohlV W Rahlfs
Aug 27, 2005·Diabetes Care·Marinos EliaRebecca J Stratton
Nov 18, 2005·Lancet·Vincent Falanga
Mar 7, 2006·Cell Metabolism·Daniel J Drucker
Jun 21, 2006·Circulation·Alice H LichtensteinJudith Wylie-Rosett
Sep 19, 2006·Metabolism: Clinical and Experimental·Vikkie A MustadBrad Zinker
Dec 29, 2006·Diabetes Care·UNKNOWN American Diabetes Association
Citations
Nov 28, 2012·European Journal of Nutrition·Cruz Erika García-RodríguezAngel Gil
Dec 21, 2010·Current Diabetes Reports·Michael A Via, Jeffrey I Mechanick
May 18, 2010·Diabetes Technology & Therapeutics·Carolyn J AlishVikkie A Mustad
Nov 21, 2014·Nutrients·Omorogieva Ojo, Joanne Brooke
Oct 19, 2010·Nutrition·Michael D RobertsChad M Kerksick
Oct 13, 2009·Nutrition·Alaa Al-KhalifaHussein M Dashti
Jul 28, 2016·Nutrients·Adham MottalibOsama Hamdy
Sep 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Osama HamdyRefaat Hegazi
Aug 24, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Cynthia Hamilton, Victoria J Boyce
Apr 23, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Roland N DickersonRex O Brown
Jul 13, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Yuan ShaoGang Hu
Feb 7, 2020·Nutrients·Vikkie A MustadRicardo Rueda
Feb 25, 2017·Journal of Strength and Conditioning Research·Megan M HetrickRobert R Kraemer
Nov 10, 2015·Critical Care : the Official Journal of the Critical Care Forum·Alfonso MesejoFátima Martinez-Lozano
Jul 28, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Vishal Nainesh PatelHelen L MacLaughlin
Jul 3, 2019·Nutrients·Lisse Angarita DávilaJose López-Miranda
Aug 25, 2019·Nutrients·Omorogieva OjoXiao-Hua Wang
Jul 29, 2020·BMJ Open Diabetes Research & Care·Vikkie A MustadOsama Hamdy
Jan 29, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Yatin MehtaSameer Rao