Effect of type-specific human papillomavirus incidence on screening performance and cost

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Theodoros AgorastosChristos J Emmanouilides

Abstract

Implementation of human papillomavirus (HPV) vaccination is expected to change the epidemiology of HPV infection. Using age-dependent (inhomogeneous) Markov chains, we tested the effect of type-specific (ie, HPV-16/HPV-18 and other high-risk HPV types) HPV incidence on 3 screening strategies in a cohort of 100,000 women, starting screening at the age of 25 years and continuing until the age of 34 years. All the strategies started with an HPV test; if the result was positive, the next step was triage with cytology (strategy 1), cytology and colposcopy together (strategy 2), or colposcopy only (strategy 3). Published background data were used for the models. Strategy 2 had the highest sensitivity; the absolute number of missed cervical intraepithelial neoplasia (CIN)3+ cases was associated with HPV incidence in all the strategies, but their relative sensitivity remained unaffected. Strategy 2 was cheaper per diagnosed CIN3+ for very low HPV incidence rates, but this changed for higher incidence rates. For any given pair of HPV-16/HPV-18 and other high-risk-type incidence, the cost of the triage and the total cost of screening was highest in screening 2 and lowest in screening 1. For each screening strategy, the cost per diagnosed...Continue Reading

References

Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Jan 13, 2000·JAMA : the Journal of the American Medical Association·M SchiffmanA T Lorincz
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Jun 16, 2005·Journal of the National Cancer Institute·Jane J KimSue J Goldie
Mar 24, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·V M H CoupéC J L M Meijer
Oct 19, 2007·The New England Journal of Medicine·Marie-Hélène MayrandUNKNOWN Canadian Cervical Cancer Screening Trial Study Group
Oct 19, 2007·The New England Journal of Medicine·Pontus NauclerJoakim Dillner
Mar 28, 2008·Journal of the National Cancer Institute·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer Screening Working Group
Oct 14, 2008·Vaccine·Patti E GravittCosette M Wheeler

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Citations

Sep 16, 2010·Annals of the New York Academy of Sciences·Theodoros AgorastosKonstantinos Chatzigeorgiou
Aug 1, 2015·Cancer Cytopathology·Lyndsay Ann RichardsonUNKNOWN PEACHS (Pap Efficacy After Cervical HPV Status) Study Consortium

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