Effect of ultrasound on transdermal drug delivery to rats and guinea pigs

The Journal of Clinical Investigation
D LevyR Langer

Abstract

The effect of therapeutic range ultrasound (1 MHz) on skin permeation of D-mannitol, a highly polar sugar alcohol, inulin, a high molecular weight polysaccharide and physostigmine, a lipophilic anticholinesterase drug was studied in rats and guinea pigs. D-Mannitol and inulin are totally and rapidly excreted, once they have penetrated through the skin into the blood stream, permitting direct in vivo monitoring. For evaluating skin penetration of physostigmine the decrease of whole blood cholinesterase was measured. Ultrasound nearly completely eliminated the lag time usually associated with transdermal delivery of drugs. 3-5 min of ultrasound irradiation (1.5 W/cm2 continuous wave or 3 W/cm2 pulsed wave) increased the transdermal permeation of inulin and mannitol in rats by 5-20-fold within 1-2 h following ultrasound application. Ultrasound treatment also significantly increased (P less than 0.05) the inhibition of cholinesterase during the first hour after application in both physostigmine treated rats and guinea pigs: while in control guinea pigs no significant inhibition of cholinesterase could be detected during the first 2 h after application of physostigmine, the ultrasound treated group showed a 15 +/- 5% (mean +/- SEM) ...Continue Reading

References

Mar 1, 1975·Analytical Biochemistry·C D Johnson, R L Russell
Jan 1, 1988·Annual Review of Medicine·L Brown, R Langer
Oct 1, 1985·British Journal of Clinical Pharmacology·J C McElnayD F McCafferty
Mar 15, 1967·Annals of the New York Academy of Sciences·H I Maibach, R J Feldmann
Oct 1, 1983·Journal of Pharmaceutical Sciences·L R BrownR Langer
Jan 1, 1984·European Journal of Clinical Pharmacology·D Arndts, K Arndts
Nov 1, 1981·Physics in Medicine and Biology·G R ter Haar, S Daniels
Feb 12, 1965·Science·Y GUTMANW E LASSITER

❮ Previous
Next ❯

Citations

Jan 1, 1991·Molecular Aspects of Medicine·B W Barry
Apr 1, 1992·Trends in Biotechnology·J Kost, R Langer
Mar 17, 2004·Advanced Drug Delivery Reviews·Samir Mitragotri, Joseph Kost
Aug 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·V FrenkelY Iger
Sep 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit Joshi, Jaideep Raje
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mizue MutohYasunori Morimoto
Mar 22, 2001·Advanced Drug Delivery Reviews·J Kost, R Langer
Jan 5, 2002·Advanced Drug Delivery Reviews·Akihiko Kikuchi, Teruo Okano
Oct 29, 2002·Ultrasound in Medicine & Biology·Ludwig J Weimann, Junru Wu
Mar 28, 2003·Ultrasound in Medicine & Biology·Nadine Barrie SmithK Kirk Shung
Nov 27, 1999·Ultrasound in Medicine & Biology·V FrenkelY Iger
Mar 7, 2002·International Journal of Pharmaceutics·T TeraharaR Langer
Aug 15, 2002·International Journal of Pharmaceutics·L Machet, A Boucaud
Oct 25, 2002·Diabetes Technology & Therapeutics·Joseph Kost
Feb 3, 2005·Diabetes Technology & Therapeutics·Seungjun LeeNadine Barrie Smith
May 24, 2005·Skin Pharmacology and Physiology·T HikimaH I Maibach
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·M Machluf, J Kost
Jan 22, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·André X C N ValenteDavid A Edwards
Jan 28, 2014·Advanced Drug Delivery Reviews·Aharon AzaguryJoseph Kost
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Anubhav AroraSamir Mitragotri
Apr 29, 2015·Annales de dermatologie et de vénéréologie·C LavogiezS Mordon
Nov 22, 2005·Expert Opinion on Drug Delivery·William G PittBryant J Staples
Dec 9, 2010·Drug Delivery·B R GandhiP P Gandhi
Jul 2, 2005·Expert Opinion on Investigational Drugs·G Cevc
Jul 19, 2012·Journal of Pharmaceutical Sciences·Kalpana S PaudelAudra L Stinchcomb
Jan 10, 2002·Journal of Pharmaceutical Sciences·Ahmet TezelSamir Mitragotri
Feb 9, 2002·Journal of Pharmaceutical Sciences·Ahmet TezelSamir Mitragotri
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyle T RichT Douglas Mast
Feb 7, 2012·The Journal of Hand Surgery·Tristan L HartzellMojca Herman
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Aug 12, 2008·Ultrasound in Medicine & Biology·Gabriel Y F Ng, Richard Y F Wong
Aug 25, 2004·The Journal of Pharmacy and Pharmacology·Limary M CancelAbdellaziz Ben-Jebria
Jun 10, 2009·The Journal of Pharmacy and Pharmacology·Rekha Rao, Sanju Nanda
Jul 29, 2004·Drug Discovery Today·Ilana Lavon, Joseph Kost
Sep 28, 1998·Archives of Physical Medicine and Rehabilitation·D P MooreS C Kazmierczak
Jan 27, 2010·Pharmaceutical Development and Technology·Mahasen MeshaliYasser El-Malah
Dec 30, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao Han, Diganta Bhusan Das

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