Apr 1, 1976

Effect of ultraviolet radiation on pinocytosis in Amoeba proteua

Acta Physiologica Scandinavica
J O Josefsson, S E Hansson

Abstract

Ultraviolet (UV) irradiation (4 000-10 000 erg X mm(-2) decreased membrane potential and input resistance of Amoeba proteus and induced formation of pinocytotic channels. Submaximal pinocytosis induced by UV light was additive to pinocytosis induced by K+ or Na+ and stimulated in the presence of EGTA. It was not inhibited by the presence of La+++ or by pretreatment with dibucaine. In these respects and with respect to optimum pH and pCa, UV induced pinocytosis. Accumulation of K+ in the amoeba membrane after a dose of radiation may explain the similarity between pinocytosis induced by UV light and potassium salts. Ca++ present during the period of irradiation inhibited the effect of UV light. Instead Ca++ applied after irradiation (1-20 mM) increased channel formation. This effect was stimulated the presence of local anesthetic drugs. It is suggested that high doses of UV light may induce channel formation by releasing Ca++ from the cell membrane into the cell (UV induced pinocytosis). Ca++ may be released at the moment of absorption of UV light in the membrane as well as during the period of depolarization which follows irradiation. Low doses of UV light may permit extracellular Ca++ to enter the cell and stimulate channel for...Continue Reading

  • References10
  • Citations3

Mentioned in this Paper

Amoeba proteus
Calcium [EPC]
Extracellular
Calcium
Dibucaine
Depressed - Symptom
Sovcaine
Amoeba genus
Resting Potentials
Potassium

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