Feb 1, 1976

Effect of unilateral and bilateral castration and cryptorchidism on serum gonadotrophins in the rat

The Journal of Endocrinology
W R Gomes, S K Jain

Abstract

The effects of unilateral and bilateral cryptorchidism and castration on serum concentrations of testosterone, FSH and LH in adult male rats were examined. The results provide no evidence for compensatory growth or development of the remaining scrotal testes up to 32 days after unilateral castration, although the scrotal testis of unilaterally cryptorchid rats showed enlargement when compared with those of control rats (P less than 0 - 05) at 32 days. Unilateral treatments had few significant effects on serum hormones, but testosterone was increased on day 4 (P less than 0 - 05) in unilaterally cryptorchid rats and on day 32 (P less than 0 - 05) in unilaterally castrated rats, compared with controls, and FSH levels were higher in unilaterally castrated rats on day 16 (P less than 0 - 05). Bilateral cryptorchidism caused an increase in serum FSH within 4 days (P less than 0 - 05) and in serum LH by 8 days (P less than 0-05) after surgery, with both hormones reaching levels double those found in control rats (P less than 0 - 01) by day 16, while testosterone levels were maintained at or above control values. Bilateral castration resulted in a marked decrease in testosterone levels (P less than 0 - 01) and a sharp increase in seru...Continue Reading

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Mentioned in this Paper

Testosterone Measurement
Benign Neoplasm of Testis
Cryptorchidism
Scrotum
Neoplasm of Uncertain or Unknown Behavior of Testis
Inferior Colliculus
Testis
Testosterone
Follicle Stimulating Hormone
Gonadotropins Measurement

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