Effect of unilateral endobronchial valve insertion on pulmonary ventilation and perfusion: a pilot study

Respirology : Official Journal of the Asian Pacific Society of Respirology
Steven C S ChungAlvin J Ing

Abstract

The effects of bronchoscopic lung volume reduction (BLVR) on pulmonary ventilation and perfusion are incompletely understood. In this pilot trial, we investigated serial changes in regional ventilation and perfusion following unilateral endobronchial valve placement in COPD patients with heterogeneous emphysema. At baseline and at days 30 and 90 following BLVR, subjects underwent lung function, 6MWD and St George's Respiratory Questionnaire. Ventilation and perfusion scintigraphy were performed to quantitate and serially compare regional differences. Six out of eight subjects completed the study; all had endobronchial valves targeting their left upper lobe. At day 90 post-BLVR, there was a trend towards an increase in FEV(1) and a mean reduction in St George's Respiratory Questionnaire score of nine units. In the targeted left upper zone there was reduced ventilation and perfusion. Ventilation and perfusion to the right lung; and specifically the right lower zone, significantly increased. There appears to be redistribution of ventilation and perfusion to the contralateral lung following endobronchial valve placement. This may be of importance when assessing patients for unilateral BLVR. Selecting patients with heterogeneous dis...Continue Reading

References

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Citations

Sep 5, 2012·Interactive Cardiovascular and Thoracic Surgery·Anupama BaruaBabu Naidu
Jan 20, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Peter R EastwoodToby M Maher
May 29, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Imran H IftikharAli I Musani
Nov 20, 2013·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Sunny J GandhiPalaniswamy Shanmuga Sundaram
Apr 29, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sridhar RathinamDavid A Waller
Apr 24, 2013·Journal of Bronchology & Interventional Pulmonology·Neethi VenkatappaThomas R Gildea
Jan 1, 2010·Seminars in Thoracic and Cardiovascular Surgery·Armin Ernst, Devanand Anantham
Aug 26, 2014·Chronic Respiratory Disease·Imran H IftikharAli I Musani
Nov 2, 2014·The European Respiratory Journal·Carmen PizarroDirk Skowasch
Dec 29, 2013·Journal of Applied Physiology·Leigh M Seccombe, Matthew J Peters
Jun 6, 2019·Respiration; International Review of Thoracic Diseases·Jonas F KristiansenJann Mortensen

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