PMID: 2105408Jan 1, 1990

Effect of uremia and its treatment on pulmonary function

D J Prezant


Alterations in respiratory drive, mechanics, muscle function, and gas exchange are frequent if not invariable consequences of uremia. Pulmonary dysfunction may be the direct result of circulating uremic toxins or may result indirectly from volume overload, anemia, immune suppression, extraosseous calcification, malnutrition, electrolyte disorders, and/or acidbase imbalances. The pulmonary system is unique because it is affected by the disease and its treatment. Acetate hemodialysis reduces alveolar ventilation and PaO2 due to extrapulmonic CO2 unloading. Peritoneal dialysis increases alveolar ventilation and intraperitoneal pressure. The latter leads to an elevated and lengthened diaphragm, a reduced functional residual capacity, basilar atelectasis, possible hypoxemia, and altered respiratory muscle function. In patients on chronic peritoneal dialysis, adaptations may occur that limit the reductions in lung volumes, PaO2, and respiratory muscle strength that are often observed during acute peritoneal dialysis. This review details how uremia and dialysis interact to alter pulmonary function.


Aug 1, 1976·Journal of Applied Physiology·R W HamiltonA P Fishman
Feb 1, 1977·Anesthesiology·T KolobowJ E Pierce
Oct 20, 1977·The New England Journal of Medicine·N M AurigemmaE G Lowrie
Apr 1, 1975·Annals of Internal Medicine·L E MalletteW K Engel
Oct 1, 1978·The American Journal of Clinical Nutrition·W H HörlA Heidland
Mar 1, 1975·Chest·M D BischelJ G Mohler
Feb 1, 1975·Thorax·H Y LeeA M Barnes
Sep 1, 1978·Journal of Neuropathology and Experimental Neurology·S J PublicoverJ L Smith
Jun 1, 1979·Critical Care Medicine·S KramanN Seriff
Jul 1, 1979·The American Journal of the Medical Sciences·R D FairshterA R Fugl-Meyer
Oct 1, 1979·Archives of Internal Medicine·F Dumler, N W Levin
Nov 1, 1979·Critical Care Medicine·G C CarlonA D Turnbull
Jan 1, 1978·Nephron·N TolchinE J Lewis
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·S MahajanF McDonald
Jan 1, 1986·Respiration; International Review of Thoracic Diseases·T H RossingJ W Weiss
Aug 1, 1987·The American Review of Respiratory Disease·W A De BackerM E De Broe
Jan 1, 1988·Respiration; International Review of Thoracic Diseases·H BarkM Mostoslovski
Jan 1, 1988·Blood Purification·A DanielssonJ Bergström
Jan 1, 1987·American Journal of Nephrology·P Gómez-FernándezM J Vila Dupla
Dec 1, 1986·Kidney International·Y BouffardJ Motin
Sep 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A R Eiser
Dec 1, 1985·Journal of Applied Physiology·S H LoringN T Griscom
Jul 9, 1966·Lancet·G M BerlyneJ A Woolcock
Aug 1, 1973·The American Journal of Medicine·A ZidulkaN R Anthonisen
Jul 3, 1971·British Medical Journal·S Freedman, D J Maberly
Dec 1, 1969·Annals of Internal Medicine·B J RosenbaumS G Massry
May 1, 1971·British Medical Journal·M J Goggin, A M Joekes
Aug 1, 1968·Archives of Surgery·R L LawtonN P Rossi
May 1, 1984·The American Review of Respiratory Disease·H RomaldiniP D Wagner
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·P SebertL Barthelemy
Jan 1, 1984·Contributions to Nephrology·J SherlockJ Letteri
Jan 1, 1983·Acta Neuropathologica·J BautistaE Rafel
May 1, 1984·The Journal of Clinical Investigation·D D RalphM P Hlastala
Feb 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W PattersonS F Sullivan
Jul 9, 1981·The New England Journal of Medicine·M J DolanK Wasserman
Jul 1, 1982·Archives of Internal Medicine·C B Burns, D J Scheinhorn
May 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M I Sheldon, J F Green
Jan 1, 1982·Nephron·H RomaldiniO R Ratto
Jan 1, 1983·Kidney International·Z J TwardowskiL M Lampton
Jun 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Farkas, C Roussos
May 1, 1983·Kidney International·W A De BackerM E De Broe
Aug 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N M BraunD F Rochester
Nov 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G A Farkas, C Roussos
Jan 1, 1982·American Journal of Nephrology·A R EiserM S Neff
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie
Jan 1, 1981·Respiration; International Review of Thoracic Diseases·H G HeinzmannM H Lavietes
Jan 1, 1981·British Journal of Diseases of the Chest·J W FormanW C Miller
Sep 1, 1980·Archives of Neurology·R P Lazaro, H S Kirshner
Aug 1, 1953·The Journal of Clinical Investigation·J M WELLERJ P MERRILL
Jul 1, 1963·Journal of Applied Physiology·H G PAULI, F REUBI
Jun 1, 1965·Metabolism: Clinical and Experimental·A S BLUMENTALSR O MULHAUSEN


May 17, 2006·Wiener klinische Wochenschrift·Susanne M LangHelmut Schiffl
May 24, 2005·Journal of Voice : Official Journal of the Voice Foundation·Abdul-Latif HamdanNabil Fuleihan
Sep 29, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J V ConteJ B Orens
Apr 1, 1993·Archives of Disease in Childhood·C H CromptonD F Geary
Jul 1, 1995·Thorax·U ZifkoT Wanke
Sep 1, 1991·European Journal of Pediatrics·K PaulK Schärer
Nov 3, 2006·Critical Care Medicine·José Mauro VieiraDaniel Deheinzelin
Aug 8, 2015·Hemodialysis International·Louis L PlesnerKasper Iversen
Nov 28, 2013·Journal of Voice : Official Journal of the Voice Foundation·Soo Yeon JungHan Su Kim
Jan 3, 2012·Paediatric Respiratory Reviews·Nelson L Turcios
Jun 4, 1999·The Annals of Thoracic Surgery·G C HughesJ E Lowe
Apr 25, 2007·Scandinavian Journal of Urology and Nephrology·Joginder SidhuUpdesh Sidhu
Aug 1, 2015·BioMed Research International·Valentina Forni OgnaRaphaël Heinzer
Jun 18, 2016·Journal of Physical Therapy Science·José Roberto Sostena NetoCarolina Kosour
Jun 24, 2016·American Journal of Respiratory and Critical Care Medicine·Faeq Husain-SyedClaudio Ronco
May 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lise H NielsenOle S Søgaard
Aug 23, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Saime Sagiroglu, Adem Doganer
Dec 15, 2006·Journal of the American Society of Nephrology : JASN·Thomas S HokeSarah Faubel
Apr 8, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Raquel P CarboneraJanice Luisa Lukrafka
Mar 19, 2013·Molecular Medicine Reports·Hui LinMing Kan
Aug 5, 2020·BMC Nephrology·Thatsaphan SrithongkulChristopher T Chan
Dec 23, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Demetria KovelisAntônio Fernando Brunetto
Dec 22, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Ashima SharmaPawan Kumar Prasher
Oct 31, 2018·International Journal of Environmental Research and Public Health·Shih-Ting HuangTzu-Chieh Chou
Nov 10, 2007·The International Journal of Artificial Organs·J RyszD Nowak

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