PMID: 9533639Apr 9, 1998Paper

Effect of urocortin and its interaction with adrenocorticotropin (ACTH) secretagogues on ACTH release

Peptides
M OzawaT Yoshimi

Abstract

We examined the effect of urocortin (Ucn) on the adrenocorticotropin (ACTH) release from cultured rat anterior pituitary cells and AtT 20 cells. Synthetic rat (r)Ucn was not soluble in 0.1 N HCl but soluble in alkaline solvents with diminished corticotropin-releasing activity. rUcn dissolved in 0.1 M sodium phosphate buffer as a stock solution maintained its bioactivity and had the equal corticotropin-releasing activity with rat/human corticotropin-releasing factor (r/hCRF). rUcn stimulated the adrenocorticotropin release via CRF-receptors accompanied by the additive effect with r/hCRF, the synergistic effect with arginine vasopressin and the dose-dependent inhibition of a potent CRF-receptor antagonist.

References

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Citations

Aug 15, 2002·Life Sciences·Keiichi IkedaKazuwa Nakao
Jul 28, 1999·Peptides·F WatanabeH Sasano
Sep 21, 2000·Neuroscience Letters·J H ParkK L Kim
Oct 1, 2004·The Journal of Comparative Neurology·Mariarosa G SpinaMario Engelmann
Nov 16, 2004·Molecular and Cellular Endocrinology·Guck T OoiRuth M Escalona
Jul 17, 2004·Regulatory Peptides·Frank M DautzenbergOlaf Brauns
Jun 22, 1999·General and Comparative Endocrinology·D A Lovejoy, R J Balment
Dec 15, 2007·Progress in Neurobiology·Weihong Pan, Abba J Kastin
Apr 14, 2005·Endocrine Reviews·John R Lindsay, Lynnette K Nieman
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·E ItagakiH Ishida
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Alison C HollowayJohn R G Challis
Mar 28, 2001·Annals of the New York Academy of Sciences·C M Bamberger, A M Bamberger
Oct 18, 2000·Regulatory Peptides·K H SkeltonC B Nemeroff

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