Jan 1, 1992

Effect of ursodeoxycholate on pancreatic exocrine secretion in vitro and in vivo study

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
H ShinozakiK Kitani


In the present study, we examined the effect of ursodeoxycholate (UDCA) and it's taurine conjugate (TUDC) on rat pancreatic exocrine secretion using dispersed pancreatic acini (in vitro) and conscious rats (in vivo). In in vitro study 300 microM UDCA significantly increased 10(-12)-10(-9) M CCK-8 stimulated amylase release and change of intracellular Ca2+ concentration, but TUDC did not have these effects. In in vivo study intraduodenal infusion of UDCA but not TUDC stimulated pancreatic exocrine secretion. Intravenous infusion of secretin antibody decreased bicarbonate output, however, this increase was not prevented by CCK antagonist. Thus, it was suggested that UDCA has direct action on pancreatic acini and UDCA infused intraduodenally stimulates pancreatic secretion, possibly via the release of a secretin-like substance. The taurine conjugate has weak bioactivity on pancreatic exocrine secretion in both in vitro and in vivo.

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Mentioned in this Paper

Pancreatic Exocrine Secretion
Pancreatic Secretion Function
August Rats
Antagonist Muscle Action
Secretin Measurement
Amylase Measurement
Pancreatic Juice

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