Abstract
Ursodeoxycholic acid (UDCA) has been shown to improve pruritus, alanine aminotransferase (ALT), and cholesterol levels in children with intrahepatic cholestatic liver disease. However, the effect of UDCA on quantitative tests of hepatic function in children is uncertain. A 2.5-year, open label, crossover study, was designed to determine the effect of UDCA (15-20 mg/kg per day for 12 months, off for 6 months, and on again for 12 months) on clinical symptoms, biochemical test results, galactose and caffeine elimination half-lives (t1/2), and quantitative hepatic scintigraphy in 13 subjects aged 13.1 +/- 2.1 years (10 of whom completed the entire study), with intrahepatic cholestasis. Pruritus improved with UDCA in the 6 patients with pruritus on entry into the study. At 12 months, there was a significant decline in ALT, gamma-glutamyl transpeptidase, and plasma levels of copper and manganese, with no further decline in these levels at 24 months. There were no changes in bilirubin or cholylglycine levels. After therapy was discontinued at 12 months, UDCA was restarted within 1 month in 9 of 12 patients in response to a doubling of ALT (n = 6) or worsening pruritus (n = 3). Galactose t1/2 increased after 12 months, with no further ...Continue Reading
References
May 1, 1979·The Medical Clinics of North America·D H Brody, L Leichter
Oct 1, 1979·The American Journal of Clinical Nutrition·J G BieriG L Catignani
Dec 1, 1976·Gut·L RanekN Tygstrup
Jul 1, 1992·The Journal of Pediatrics·C GalabertJ P Chazalette
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C ColomboK D Setchell
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ReichenJ Cotting
Apr 1, 1990·The American Journal of Clinical Nutrition·M S MoureyO Amédée-Manesme
Aug 1, 1990·Gut·J CottingJ Reichen
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NakagawaK D Setchell
Nov 1, 1988·Acta paediatrica Scandinavica·T Sveger
Mar 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·B W ShawJ Vanderhoof
Apr 1, 1988·Clinical Science·N R ScottM Y Morgan
Jul 1, 1988·Gastroenterology·P F Whitington, G L Whitington
Nov 1, 1986·The Journal of Surgical Research·W J SchirmerD E Fry
Feb 1, 1985·The Journal of Pediatrics·W F Balistreri
Jun 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R E BelseyJ T Potts
Dec 18, 1972·Annals of the New York Academy of Sciences·M K HorwittM T Searcy
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jan 1, 1983·Clinical Pediatrics·S Watson, G P Giacoia
Dec 1, 1984·Digestive Diseases and Sciences·K MiyazakiA Koga
Nov 1, 1984·European Journal of Pediatrics·M BeckerO Leiss
May 1, 1983·The Journal of Pediatrics·G NebbiaD Alagille
Aug 1, 1995·The Journal of Pediatrics·E J HoffenbergR J Sokol
Feb 1, 1994·Journal of Pediatric Gastroenterology and Nutrition·P F WhitingtonH L Sharp
Aug 1, 1994·Seminars in Liver Disease·C ColomboM Podda
May 12, 1994·The New England Journal of Medicine·R E PouponB Balkau
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteL J Scully
Jan 1, 1994·Journal of Hepatology·A StiehlL Theilmann
Mar 1, 1993·Journal of Hepatology·P M BattezzatiF Manenti
Jan 1, 1993·Journal of Hepatology·A HolstegeW Gerok
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C ColomboA Giunta
Mar 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·E A BaylissJ R Lilly
Oct 1, 1996·Journal of Hepatology·F SalernoA Ascione
Citations
Sep 5, 2003·Current Treatment Options in Gastroenterology·Valeria C. Cohran, James E. Heubi
Sep 5, 2003·Current Treatment Options in Gastroenterology·Maria R. Mascarenhas
Sep 16, 2005·Current Treatment Options in Gastroenterology·Vicky Lee Ng, William F Balistreri
Aug 5, 2010·Indian Pediatrics·Deepa SharmaSujit K Chowdhary
Apr 13, 1999·Gastroenterology Clinics of North America·R J Bahar, A Stolz
Feb 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·R J Sokol, P R Durie
Feb 5, 1999·Journal of Pediatric Gastroenterology and Nutrition·W RebhandlE Horcher
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·M R Narkewicz
Feb 27, 2003·Journal of Pediatric Gastroenterology and Nutrition·Michael R NarkewiczRonald J Sokol
Mar 15, 2012·Journal of Gastroenterology and Hepatology·Mohamad H ImamKeith D Lindor
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Mar 1, 2011·Paediatric Drugs·Samar H Ibrahim, Keith D Lindor
May 2, 2014·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Maxime ThibaultIbrahim Mohamed
Jan 22, 2004·Chest·James R YankaskasDavid Rodman
Aug 4, 2011·Clinics and Research in Hepatology and Gastroenterology·Andreas E KremerUlrich Beuers
Feb 14, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·UNKNOWN ASPEN Board of Directors and the Clinical Guidelines Task Force
Oct 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Benjamin L Shneider, George V Mazariegos
May 24, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeffrey J Cies, John N Giamalis
May 19, 2010·Journal of Pediatric Gastroenterology and Nutrition·Binita M KamathDavid A Piccoli
Nov 3, 2010·Scandinavian Journal of Gastroenterology·Aksel LangeSusanne Keiding
Apr 27, 2013·Journal of Pediatric Gastroenterology and Nutrition·Victoria KronstenAlastair Baker
Mar 29, 2001·Journal of Clinical Gastroenterology·S Nousia-ArvanitakisA Galli-Tsinopoulou
Feb 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Frank A J A BodewesHenkjan J Verkade
Jul 3, 2021·Seminars in Liver Disease·Taisa J KohutKathleen M Loomes