Effect of Vacuum Assisted Closure Therapy on early systemic cytokine levels in a swine model

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Deepak V KilpadiWilliam A Wooden

Abstract

Vacuum Assisted Closure (V.A.C.) Therapy has previously been shown to facilitate healing of wounds. However, the physiological mechanism(s) of this treatment modality and its systemic effects require further investigations. The goal of this porcine study was to investigate the effect of V.A.C. Therapy on the systemic distribution of the inflammatory cytokines interleukin (IL)-6, IL-8, IL-10, and transforming growth factor-beta1. Twelve pigs were each given one full-thickness excisional wound, using electrocautery. Six of the pigs were treated with V.A.C. Therapy and six with saline-moistened gauze. Serum samples were collected immediately after wound creation, and hourly for 4 hours. Samples were analyzed using commercially available enzyme-linked immunosorbent assay kits. During the initial 4 hours of treatment, V.A.C. Therapy resulted in earlier and greater peaking of IL-10 and maintenance of IL-6 levels compared with saline-moistened gauze controls, which showed decreased IL-6 values over the first hour (both at p<0.05). No other treatment-based differences were detected.

References

Jan 1, 1992·The Journal of Surgical Research·K BreuingD R Miller
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R M StrieterS L Kunkel
Sep 1, 1985·Equine Veterinary Journal·J A Mumford
Nov 1, 1994·The Journal of Experimental Medicine·S M Wahl
Jul 1, 1996·The American Journal of Physiology·L A DielemanK W Beagley
Apr 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Kitamura, T S Sütö
Sep 1, 1997·Plastic and Reconstructive Surgery·K BreuingE Eriksson
Nov 24, 1998·Inflammation·Z B RavageG O Till
Aug 2, 2000·The Journal of Physiology·T CartmellG N Luheshi
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R M GallucciM I Luster
Apr 20, 2001·The Australasian Journal of Dermatology·G J Goodman
Jun 20, 2001·Immunology·C A Akdis, K Blaser
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B RoyerM Arock
Jun 26, 2001·Journal of the American Academy of Dermatology·C I JacobM S Kaminer
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·F YaoE Eriksson
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian EndlichThomas A Hamilton
Nov 28, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Karola Vorauer-UhlHermann Katinger
Feb 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Traci A WilgusTatiana M Oberyszyn
Jul 9, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Elizabeth A BakerDavid J Leaper
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Mikael MazighiLaurent J Feldman
Jul 1, 1996·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·R W Tarnuzzer, G S Schultz

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Citations

Jun 5, 2007·Der Unfallchirurg·G HolleG Germann
Sep 4, 2008·Plastic and Reconstructive Surgery·Sandra Saja SchererDennis P Orgill
Apr 1, 2014·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·L Kobayashi, R Coimbra
Feb 3, 2016·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·M C Nolff, A Meyer-Lindenberg
Jan 13, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Graeme E Glass, Jagdeep Nanchahal
Sep 27, 2007·Veterinary Surgery : VS·Ron Ben-AmotzMichael D King
Jul 21, 2011·Veterinary Surgery : VS·Marco DemariaHeather S Hadley
Oct 9, 2014·The British Journal of Surgery·G E GlassJ Nanchahal
Aug 12, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cornelia Sigrid Lissi MüllerClaudia Pföhler
Aug 12, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cornelia Sigrid Lissi MüllerClaudia Pföhler
Aug 22, 2014·The Journal of Bone and Joint Surgery. American Volume·Geoffrey WilkinSteven Papp
Oct 30, 2012·Journal of Wound Care·S L A Jeffery
May 16, 2012·Journal of Wound Care·M KhanbhaiT Richards
Jan 3, 2019·European Journal of Clinical Investigation·Sebastian BorysMaciej T Malecki
Jun 3, 2011·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·Allen GabrielSharon D Fritzsche
Aug 26, 2021·Journal of Feline Medicine and Surgery·Mirja C Nolff

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