PMID: 2494670Apr 1, 1989Paper

Effect of valproate on lactate and glutamine metabolism by rat renal cortical tubules

Proceedings of the Society for Experimental Biology and Medicine
M DovalJ M Lopez-Novoa

Abstract

The metabolic effects of sodium valproate (VPA) on rat renal cortical tubules have been examined. When 1 or 5 mM lactate was used as substrate in the incubation medium, VPA decreased markedly the lactate uptake by the tubules. When 1 or 5 mM glutamine was used, the addition of VPA accelerated glutamine uptake, ammoniagenesis, but also stimulated markedly the accumulation of lactate and pyruvate produced from glutamine. VPA had a dose-dependent inhibitory effect on gluconeogenesis from both glutamine and lactate. With 5 mM glutamine, VPA also induced a significant accumulation of glutamate in the medium. The oxygen consumption by the tubules was diminished by 40% following VPA addition. It is concluded that VPA modifies the metabolism of rat cortical tubules by interfering with the oxidation of natural substrates and stimulates in this fashion the production of ammonia by kidney tubules.

Citations

Oct 15, 1989·Biochemical Pharmacology·M CulebrasJ M López-Novoa
Sep 16, 1999·Biochemical Pharmacology·E I ZagryadskayaA A Nikiforov
Jul 28, 2009·Critical Care Medicine·Elisa LicariRinaldo Bellomo
Mar 17, 2005·Experimental Physiology·Carolina Carrasco-MartínAntonio J López-Farré
May 14, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I David Weiner

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