PMID: 9180347Jan 1, 1997Paper

Effect of valproate on the metabolism of the central nervous system

Life Sciences
J P Bolaños, J M Medina

Abstract

The effects of valproate on brain energy and lipid metabolism is reviewed. Increasing evidence suggests that valproate uses the monocarboxylic acid carrier in order to cross the blood brain barrier (BBB) and the neural cell plasma membranes. The uptake of valproate into the brain through this mechanism would compete with the uptake of energy precursors, such as the monocarboxylic acids 3-hydroxybutyrate, lactate or pyruvate and with some amino acids, but not with glucose. This could impair brain fuel utilization, specially during the neonatal period or childhood, when lactate or 3-hydroxybutyrate furnishes alternative substrates to glucose for the brain. It is concluded that valproate interference with energy metabolism may have implications for the therapeutic action of the drug, stressing the possibility that valproate-mediated alterations in brain lipid synthesis may contribute to the pharmacological action of the drug.

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Citations

Apr 25, 2000·Archives of Biochemistry and Biophysics·M MacK A Nałecz
May 28, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wafa Ben-CherifNaceur A Boughattas
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May 12, 2012·Journal of Circadian Rhythms·Wafa Ben-CherifNaceur A Boughattas
Nov 9, 2010·Molecular Genetics and Metabolism·Joseph VamecqGilbert Briand
Jan 12, 2010·Journal of Affective Disorders·Hui Hua ChangRu Band Lu
Sep 8, 2010·Developmental Disabilities Research Reviews·Fernando Scaglia
Mar 13, 2012·Cancer Biology & Therapy·Yong TangPaul Dent
Jul 15, 2016·Neurochemical Research·Mikko GyntherKristiina M Huttunen
Jun 26, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wiebke FischerMatthias Brandsch
Dec 2, 2004·Canadian Journal of Physiology and Pharmacology·Thomas DanielsRobert L Rodgers
Sep 9, 2005·Journal of Cellular Biochemistry·Hei Yi WongYuan Yuan Ho
Jul 15, 2020·Clinical and Experimental Pharmacology & Physiology·Jyoti UpadhyayMohd Nazam Ansari

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