Effect of vanadium in the +5, +4 and +3 oxidation states on cardiac force of contraction, adenylate cyclase and (Na+ + K+)-ATPase activity

Biochemical Pharmacology
W SchmitzK Werdan


The influence of vanadium in the nominally +5 (NH4VO3; referred to as V5+), +4 (C10H14O5V and VOSO4; V4+) and +3 oxidation states (VCl3; V3+) on cardiac force of contraction, adenylate cyclase and (Na+ + K+)-ATPase activity was investigated in order to determine which form of vanadium mediates the cardiac effects. V5+, V4+ and V3+ (300 microM each) increased the force of contraction of isolated electrically driven cat papillary muscles by about 100%. In the presence of the reducing agent ascorbic acid (5 mM) none of the three compounds led to any distinct increase in force of contraction. On the particulate adenylate cyclase preparation from feline right ventricles only V5+ stimulated the enzyme activity by about 100%, whereas V4+ and V3+ were ineffective. In the presence of 5 mM ascorbic acid all three compounds were ineffective. In contrast, in the presence of the oxidizing agent diamide (azodicarboxylic acid-bis-dimethylamide; 1 mM) all three compounds became stimulatory. On the isolated (Na+ + K+)-ATPase V5+ (500 microM) alone reduced the basal activity by about 95%. In the presence of ascorbic acid the inhibitory effect of V5+ was greatly diminished. Similar results were obtained with V4+, V3+ (100 microM) alone inhibited ...Continue Reading


Aug 20, 1975·Biochimica Et Biophysica Acta·B J Pitts, A Schwartz
Jan 11, 1979·Nature·U SchwabeE Söchtig
May 28, 1979·Biochemical and Biophysical Research Communications·G GruppA Schwartz
Oct 4, 1979·Nature·T J Simons
Aug 15, 1979·Biochemical Pharmacology·W KrawietzE Erdmann
Oct 10, 1975·Biochimica Et Biophysica Acta·D RosenF L Crane
Apr 15, 1978·Experientia·E Kruse, H Scholz
Sep 7, 1978·Nature·I HackbarthG Philipp
Jul 1, 1971·Archives of Biochemistry and Biophysics·E ErdmannB Lüderitz
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Dec 26, 1973·Journal of the American Chemical Society·R N LindquistG E Lienhard
Apr 17, 1980·Biochimica Et Biophysica Acta·I G MacaraL C Cantley
May 15, 1980·Biochemical Pharmacology·I HackbarthG Philipp
May 1, 1980·Basic Research in Cardiology·W SchmitzE Wetzel
May 1, 1980·Basic Research in Cardiology·E Erdmann
Oct 1, 1963·Journal of Chronic Diseases·H A SCHROEDERI H TIPTON


Dec 31, 2010·Biological Trace Element Research·Wei CuiBangyuan Wu
Oct 1, 2011·Biological Trace Element Research·Wei CuiBangyuan Wu
Apr 25, 2012·Biological Trace Element Research·Kangping WangBangyuan Wu
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·T Nakano, T Morimitsu
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·T Nakano, T Morimitsu

Related Concepts

Na(+)-K(+)-Exchanging ATPase
Adenylate Cyclase
Felis catus
Myocardial Contraction

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.