Effect of vanadium in the +5, +4 and +3 oxidation states on cardiac force of contraction, adenylate cyclase and (Na+ + K+)-ATPase activity

Biochemical Pharmacology
W SchmitzK Werdan

Abstract

The influence of vanadium in the nominally +5 (NH4VO3; referred to as V5+), +4 (C10H14O5V and VOSO4; V4+) and +3 oxidation states (VCl3; V3+) on cardiac force of contraction, adenylate cyclase and (Na+ + K+)-ATPase activity was investigated in order to determine which form of vanadium mediates the cardiac effects. V5+, V4+ and V3+ (300 microM each) increased the force of contraction of isolated electrically driven cat papillary muscles by about 100%. In the presence of the reducing agent ascorbic acid (5 mM) none of the three compounds led to any distinct increase in force of contraction. On the particulate adenylate cyclase preparation from feline right ventricles only V5+ stimulated the enzyme activity by about 100%, whereas V4+ and V3+ were ineffective. In the presence of 5 mM ascorbic acid all three compounds were ineffective. In contrast, in the presence of the oxidizing agent diamide (azodicarboxylic acid-bis-dimethylamide; 1 mM) all three compounds became stimulatory. On the isolated (Na+ + K+)-ATPase V5+ (500 microM) alone reduced the basal activity by about 95%. In the presence of ascorbic acid the inhibitory effect of V5+ was greatly diminished. Similar results were obtained with V4+, V3+ (100 microM) alone inhibited ...Continue Reading

References

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Citations

Dec 31, 2010·Biological Trace Element Research·Wei CuiBangyuan Wu
Oct 1, 2011·Biological Trace Element Research·Wei CuiBangyuan Wu
Apr 25, 2012·Biological Trace Element Research·Kangping WangBangyuan Wu
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·T Nakano, T Morimitsu
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·T Nakano, T Morimitsu

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