Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats

Journal of Applied Toxicology : JAT
L M AppelmanW R Notten

Abstract

The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interruption, the exposure of a second group was interrupted for 1.5 h between the first and second 3-h periods, the exposure of a third group was similarly interrupted and for six 5 min periods exposure was increased sixfold. Peak exposures of up to 3000 ppm superimposed on 500 ppm acetaldehyde caused irritation and excitation, and reduced body weight gain. No such effects occurred after interrupted or uninterrupted exposure to 500 ppm acetaldehyde without peak loads. A reduced phagocytotic index of lung macrophages was found in each of the groups exposed to 500 ppm acetaldehyde, the effect being most marked in the group with superimposed peaks of 3000 ppm. Degeneration of the nasal olfactory epithelium was observed in rats uninterruptedly exposed to 500 ppm acetaldehyde. Interruption of the exposure or interruption combined with peak exposure did not visibly influence this adverse effect on the nose. No compound-related effects were seen in rats interruptedly or uninterruptedly exposed to...Continue Reading

References

Sep 1, 1975·Archives of Environmental Health·A KruysseH P Til
Mar 15, 1981·Chemico-biological Interactions·H SavolainenH Kivistö
Oct 1, 1982·Journal of Toxicology and Environmental Health·E W Van SteeR A Sloane
Jan 1, 1981·International Archives of Occupational and Environmental Health·A DavidO Nováková

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Citations

Sep 4, 2014·Archives of Toxicology·Thomas BrüningChristoph van Thriel
Jul 31, 2013·Toxicology Letters·Lata Kaphalia, William J Calhoun
Dec 20, 2011·Regulatory Toxicology and Pharmacology : RTP·Michael J OldhamWillie J McKinney
Jun 1, 1987·Journal of Applied Toxicology : JAT·M BogersW R Notten
Jan 1, 1991·Critical Reviews in Toxicology·P M BosP C Bragt

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