PMID: 36596May 15, 1979

Effect of variations in blood hydrogen ion concentration on pulmonary gas exchange of artificially ventilated dogs

Pflügers Archiv : European journal of physiology
A FransF Kreuzer

Abstract

The effect of variation of blood hydrogen ion concentration on arterial and mixed venous PO2, ideal alveolar-arterial O2 pressure difference (PAiO2--PaO2), venous admixture (Qs/Qt), arterio-alveolar CO2 pressure difference (a--A)DCO2, physiological dead space to tidal volume ratio (VD/VT), cardiac output (Qt) and mean pulmonary arterial pressure (PAP) has been studied. Arterial and mixed venous PO2 increased and (PAiO2--PaO2) decreased with increasing blood hydrogen ion concentration. No change in Qs/Qt, (a--A)DCO2, VD/VT, Qt and PAP was observed. The effect of hydrogen ion concentration on arterial and mixed venous PO2 and on (PAiO2--PaO2) is mainly due to a shift of the blood oxyhemoglobin dissociation curve (ODC), i.e. due to the Bohr effect. The upper part of the ODC is more flat in alkalosis (shift to the left) than in acidosis (shift to the right). Therefore the same end-capillary to arterial O2 content difference results in a greater (PAiO2--PaO2) in alkalosis than in acidosis. Any factor influencing the slope of the upper part of the ODC is expected to affect the arterial PO2 and the (PAiO2--PaO2) by this mechanism. Similarly any factor shifting the steep part of the ODC is expected to affect the PO2 of the mixed venous...Continue Reading

References

Mar 1, 1980·Pflügers Archiv : European journal of physiology·Z TurekF Kreuzer
May 3, 2006·American Journal of Veterinary Research·Ignacio LópezEscolástico Aguilera-Tejero
Jan 1, 1983·Respiration Physiology·C D SoulardR A Herigault

Citations

Apr 1, 1968·Journal of Applied Physiology·F Haas, E H Bergofsky
Nov 1, 1968·The American Journal of Physiology·P H Viles, J T Shepherd
Jan 1, 1966·Journal of Applied Physiology·R G Rossing, S M Cain
Sep 1, 1966·Journal of Applied Physiology·G R Kelman, J F Nunn
May 1, 1966·The American Journal of Physiology·B J ShapiroL M Linde
Jun 1, 1964·The Journal of Clinical Investigation·Y ENSONR M HARVEY

Related Concepts

Hydrogen Ion Concentration Measurement
Alveolar
Oxygen Measurement, Partial Pressure, Arterial
Oxyhemoglobin Measurement
Pulmonary Gas Exchange
Blood
Entire Capillary Blood Vessel (Organ)
In Blood
Respiration
Capillary Vessel

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