Effect of variations in temperature on antimuscarinic activity in guinea-pig atria

C K Li, F Mitchelson


The characteristics of the antimuscarinic activity of homatropine, gallamine and stercuronium in guinea-pig atria remained constant over the temperature range 22--37 degrees C in that a linear Arunlakshana-Schild plot was obtained with homatropine and nonlinear plots occurred with gallamine or stercuronium. A trend towards higher dose-ratios with reduction in temperature was only significant for gallamine.


Jan 1, 1975·European Journal of Pharmacology·H Muñoz-RamírezC K Buckner
Apr 1, 1977·British Journal of Pharmacology·G Kunos, M Nickerson
Nov 1, 1976·British Journal of Pharmacology·A L Clark, F Mitchelson
Mar 1, 1976·The Journal of Physiology·G Kunos, M Nickerson
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·D ReinhardtH J Schümann
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·M N Harri
Nov 1, 1970·Canadian Anaesthetists' Society Journal·F J Rathbun, J T Hamilton
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Oct 1, 1951·Annals of the New York Academy of Sciences·W F RIKER, W C WESCOE

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Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J E O'Shea
Oct 1, 1980·British Journal of Pharmacology·C K Li, F Mitchelson

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