Effect of varicocele on semen characteristics according to the new 2010 World Health Organization criteria: a systematic review and meta-analysis

Asian Journal of Andrology
Ashok AgarwalSandro C Esteves

Abstract

This study investigated the effects of varicocele on semen parameters in infertile men based on the new 2010 World Health Organization laboratory manual for the examination of human semen. Semen analysis results (volume, sperm count, motility, and morphology) were the primary outcomes. An electronic search to collect the data was conducted using the Medline/PubMed, SJU discover, and Google Scholar databases. We searched articles published from 2010 to August 2015, i.e., after the publication of the 2010 WHO manual. We included only those studies that reported the actual semen parameters of adult infertile men diagnosed with clinical varicocele and contained a control group of either fertile men or normozoospermic men who were not diagnosed with varicocele. Ten studies were included in the meta-analysis, involving 1232 men. Varicocele was associated with reduced sperm count (mean difference: -44.48 × 10 [6] ml-1 ; 95% CI: -61.45, -27.51 × 10 [6] ml-1 ; P < 0.001), motility (mean difference: -26.67%; 95% CI: -34.27, -19.08; P < 0.001), and morphology (mean difference: -19.68%; 95% CI: -29.28, -10.07; P < 0.001) but not semen volume (mean difference: -0.23 ml; 95% CI: -0.64, 0.17). Subgroup analyses indicated that the magnitude of...Continue Reading

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Citations

Jan 20, 2016·Asian Journal of Andrology·Ashok Agarwal, Sandro C Esteves
Jan 20, 2016·Asian Journal of Andrology·Sandro C Esteves, Ashok Agarwal
Jul 18, 2016·Journal of Assisted Reproduction and Genetics·Sandro C Esteves
Mar 17, 2017·World Journal of Radiology·Athina C TsiliMaria I Argyropoulou
Jan 3, 2019·Systems Biology in Reproductive Medicine·Viviane Paiva SantanaRosana Maria Dos Reis
Jan 10, 2020·Human Fertility : Journal of the British Fertility Society·Sandra Lara-CerrilloAgustín García-Peiró
Mar 16, 2018·International Urology and Nephrology·Matheus Roque, Sandro C Esteves
Dec 7, 2018·Cardiovascular and Interventional Radiology·Laura Maria MongioìAldo Eugenio Calogero
Sep 30, 2020·International Journal of Molecular Sciences·Luz Candenas, Rosanna Chianese
Jun 26, 2017·Journal of Endocrinological Investigation·F PallottiF Lombardo
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
May 14, 2019·The World Journal of Men's Health·Avi HarlevAshok Agarwal
Aug 7, 2019·The World Journal of Men's Health·Manesh Kumar Panner Selvam, Ashok Agarwal
Jul 9, 2020·International Journal of Immunopathology and Pharmacology·Laura Maria MongioìRosita Angela Condorelli
Jan 27, 2018·Reproductive Medicine and Biology·Yasushi YumuraTeruaki Iwamoto
Oct 5, 2018·Journal of Endocrinological Investigation·M ZavattaroF Lanfranco
Jul 29, 2020·Journal of Ultrasound·Michele BertolottoUNKNOWN Members of the ESUR-SPIWG WG
Jul 1, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
Oct 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sandro C Esteves, Marcello S Cocuzza
Jan 22, 2021·Reproductive Biology and Endocrinology : RB&E·Runqing LiQuanxian Wang
Oct 6, 2020·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Georgios TsampoukasNoor Buchholz
Mar 5, 2021·Journal of Assisted Reproduction and Genetics·Sandra Lara-CerrilloAgustín García-Peiró
May 1, 2021·Journal of Clinical Medicine·Francesco TiralongoAntonio Basile

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Software Mentioned

Comprehensive Meta - analysis ( CMA )
Biostat
Google Scholar
REM

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