PMID: 7901954Sep 1, 1993Paper

Effect of various neurotransmitters and electrical field stimulation on smooth muscle preparations from the esophagus of horses

Zentralblatt für Veterinärmedizin. Reihe A
M DenacE Scharrer

Abstract

The effects of various neurotransmitters and electrical field stimulation on muscle strips from the distal equine esophagus were studied. Acetylcholine (ACH) caused concentration dependent (1.1-55 x 10(-6) mol/l) contractions of the longitudinal and circular muscle strips from the distal esophagus as well as from the lower esophageal sphincter (LES). Atropine (10(-5) mol/l) blocked these contractions. Noradrenaline (NA) induced concentration related (1.1-55 x 10(-6) mol/l) contractions of the muscle strips from the LES. This excitatory effect of noradrenaline was antagonized by the alpha 1-receptor antagonist prazosin. Tetrodotoxin (5 x 10(-6) mol/l) did not affect the contractile response of the muscle strips to noradrenaline (55 x 10(-6) mol/l). Noradrenaline (1.1-55 x 10(-6) mol/l) had no excitatory effect on the circular and the longitudinal muscle strips from the esophagus. Furthermore, noradrenaline induced a concentration dependent (1.1-55 x 10(-6) mol/l) relaxation of the longitudinal muscle strips from the esophagus. The relaxing effect of NA was antagonized by the beta-receptor antagonist propranolol (10(-5) mol/l). Histamine (10(-7)-10(-6) mol/l) elicited a contraction in 4 out of 18 muscle preparations from the LES....Continue Reading

References

Jan 1, 1990·Experimental Physiology·M DenacE Scharrer
Apr 1, 1989·Digestive Diseases and Sciences·J ChristensenT M O'Dorisio
Mar 1, 1985·Regulatory Peptides·S AggestrupH R Sørensen
Aug 1, 1982·Acta Physiologica Scandinavica·S LeanderR Uddman
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J CristR K Goyal

Citations

Apr 16, 2005·The Journal of Pharmacy and Pharmacology·Nilberto R F NascimentoManassés C Fonteles
Jan 8, 2005·The Veterinary Clinics of North America. Equine Practice·David A Schneider, Ayman I Sayegh

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