Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea

Journal of Neurophysiology
Elizabeth P OttJacqueline K Limberg

Abstract

We sought to examine the effect of varying chemoreflex stress on sympathetic neural recruitment strategies during end-expiratory apnea. We hypothesized that increases in the firing frequency and probability of low-threshold axons at the asphyxic "break point" would be exaggerated during hypoxia and attenuated during hyperoxia. Multiunit muscle sympathetic nervous system activity (MSNA) (peroneal nerve microneurography) was measured in 10 healthy male subjects (31 ± 2 yr, 25 ± 1 kg/m2). Individuals completed maximal voluntary end-expiratory apnea under normoxic, hypoxic (inspired O2 fraction: 0.17 ± 0.01), and hyperoxic (inspired O2 fraction: 0.92 ± 0.03) conditions. Action potential (AP) patterns were examined from the filtered raw signal with wavelet-based methodology. Multiunit MSNA was increased (P ≤ 0.05) during normoxic apnea, because of an increase in the frequency and incidence of AP spikes (243 ± 75 to 519 ± 134 APs/min, P = 0.048; 412 ± 133 to 733 ± 185 APs/100 heartbeats, P = 0.02). Multiunit MSNA increased from baseline (P < 0.01) during hypoxic apnea, which was due to an increase in the frequency and incidence of APs (192 ± 59 to 952 ± 266 APs/min, P < 0.01; 326 ± 89 to 1,212 ± 327 APs/100 heartbeats, P < 0.01). Hyp...Continue Reading

References

Oct 1, 1979·Physiological Reviews·A B VallboB G Wallin
Jul 1, 1990·Circulation Research·D R SealsJ A Dempsey
Nov 1, 1989·Journal of Applied Physiology·V K SomersF M Abboud
Oct 1, 1988·Journal of Applied Physiology·M SaitoY Yamazaki
Aug 1, 1985·The Journal of Physiology·D L EckbergB G Wallin
Sep 1, 1974·Journal of Applied Physiology·Y C LinS K Hong
Oct 1, 1968·Respiration Physiology·S Godfrey, E J Campbell
Nov 1, 1968·Journal of Applied Physiology·D D HeistadJ W Eckstein
Dec 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L J FindleyP D Wagner
Jun 25, 1995·Journal of the Autonomic Nervous System·V G Macefield, B G Wallin
Jun 25, 1995·Journal of the Autonomic Nervous System·V G Macefield, B G Wallin
Dec 15, 1994·The Journal of Physiology·V G MacefieldA B Vallbo
Nov 1, 1994·Journal of Applied Physiology·J C HardyU Leuenberger
Oct 1, 1996·Journal of Applied Physiology·H F BeckerC E Sullivan
Dec 1, 1996·The American Journal of Physiology·S C MalpasG A Head
Feb 14, 1998·Journal of Applied Physiology·S KatragaddaB J Morgan
Jul 29, 1998·Circulation·P van de BorneV K Somers
Mar 15, 2001·Journal of Applied Physiology·U A LeuenbergerL I Sinoway
Aug 17, 2002·Journal of Applied Physiology·John R Halliwill, Christopher T Minson
Oct 17, 2002·Respiratory Physiology & Neurobiology·Jerome A DempseyBarbara J Morgan
Mar 1, 2003·Acta Physiologica Scandinavica·M ElamV G Macefield
Jun 24, 2003·Journal of Applied Physiology·Darija BakovićZeljko Dujić
Aug 5, 2003·The Journal of Physiology·John R HalliwillNisha Charkoudian
Sep 1, 1959·Journal of Applied Physiology·F J KLOCKE, H RAHN
Aug 30, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hisayoshi MuraiShuichi Kaneko
Nov 8, 2005·Experimental Physiology·M J Parkes
Mar 17, 2007·Respiratory Physiology & Neurobiology·Ivan PaladaZeljko Dujic
Mar 4, 2009·Hypertension·Karsten HeusserZeljko Dujic
Sep 10, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Craig D SteinbackJ Kevin Shoemaker
Sep 14, 2010·Journal of Neuroscience Methods·Aryan SalmanpourJ Kevin Shoemaker
Apr 14, 2011·The Journal of Physiology·Elisabeth A LambertGavin W Lambert
Apr 26, 2011·Autonomic Neuroscience : Basic & Clinical·Timothy B Curry, Nisha Charkoudian
Jun 7, 2011·Autonomic Neuroscience : Basic & Clinical·Toni BreskovicZeljko Dujic
Mar 24, 2012·Journal of Neurophysiology·Aryan Salmanpour, J Kevin Shoemaker
Dec 26, 2013·Autonomic Neuroscience : Basic & Clinical·Abu ShamsuzzamanVirend K Somers
Dec 1, 2014·Critical Care : the Official Journal of the Critical Care Forum·Stefano RomagnoliA Raffaele De Gaudio

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Citations

Apr 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth P OttJacqueline K Limberg
Jan 21, 2021·Seminars in Cell & Developmental Biology·Stephen A KlassenSarah E Baker

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