Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M L GraysonR C Moellering

Abstract

The susceptibility of 22 clinical isolates of Campylobacter pylori to eight antimicrobial agents was studied under varying pH conditions. Macrolides (erythromycin, dirythromycin), clindamycin and to a lesser extent quinolones lost efficacy at lowered pH. The activity of ampicillin and metronidazole remained relatively stable throughout the pH range tested. The effect of pH an antimicrobial efficacy may warrant consideration when selecting an antibiotic to clear Campylobacter pylori in vivo, since the pH of the gastric submucous environment is not known for certain.

References

Jul 1, 1988·The Journal of Antimicrobial Chemotherapy·J W StoneJ Gearty
Nov 1, 1988·The Journal of Antimicrobial Chemotherapy·D J HardyP B Fernandes
Jun 18, 1987·The New England Journal of Medicine·B DrummM Karmali
Jun 1, 1987·Antimicrobial Agents and Chemotherapy·D L ShunguB Weissberger

❮ Previous
Next ❯

Citations

Feb 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G J MalanoskiR C Moellering
Feb 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F MégraudC Camou Juncas
Apr 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y J Debets-OssenkoppD M MacLaren
Feb 17, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Mitsushige Sugimoto, Yoshio Yamaoka
Aug 17, 2006·European Journal of Clinical Pharmacology·Mateusz KurzawskiMarek Droździk
Jul 1, 1990·Diagnostic Microbiology and Infectious Disease·G M EliopoulosM L Grayson
Feb 1, 1993·Diagnostic Microbiology and Infectious Disease·W W HooverR N Jones
Apr 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C Scarpignato
Jul 1, 2003·Current Therapeutic Research, Clinical and Experimental·Kyoichi AdachiYoshikazu Kinoshita
Feb 1, 2002·Diagnostic Microbiology and Infectious Disease·A Bolmstrom, A Karlsson
Jan 1, 1997·International Journal of Antimicrobial Agents·A LozniewskiF Jehl
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Takahisa FurutaAkira Hishida
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M DojoM Kuriyama
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·K AdachiY Kinoshita
Oct 12, 1995·The New England Journal of Medicine·J H Walsh, W L Peterson
Feb 17, 2009·The Journal of Antimicrobial Chemotherapy·Klas I UdekwuBruce R Levin
Oct 1, 1998·Journal of Clinical Gastroenterology·I AdamssonR Seensalu
Feb 3, 2012·Journal of Clinical Gastroenterology·Seiji ShiotaYoshio Yamaoka
Feb 9, 2010·Journal of Gastroenterology and Hepatology·Mitsushige SugimotoYoshio Yamaoka
Jul 1, 1997·Helicobacter·G N Tytgat
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Osamu KamodaShigeru Kamiya
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Sander J O Veldhuyzen van ZantenAdrian Lee
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chikako TokoroDaisuke Takahashi
Jun 1, 2012·Clinical and Experimental Gastroenterology·Mitsushige Sugimoto, Takahisa Furuta
Jul 9, 2010·Clinical Pharmacokinetics·Ryuichi Ogawa, Hirotoshi Echizen
Feb 28, 2014·World Journal of Gastroenterology : WJG·Seung Bae YoonMyung-Gyu Choi
Mar 13, 2014·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ahmad SettinAmr Galal
Dec 9, 2009·Expert Opinion on Drug Metabolism & Toxicology·Jyh-Chin Yang, Chun-Jung Lin
May 17, 2006·Alimentary Pharmacology & Therapeutics·C Scarpignato, I Pelosini
Jun 14, 2001·Best Practice & Research. Clinical Gastroenterology·J Labenz
Oct 28, 2006·The Lancet Infectious Diseases·Monique M GerritsJohannes G Kusters

❮ Previous
Next ❯

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