Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Gugulethu Promise ShangeThajasvarie Naicker

Abstract

To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia. VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex. No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p < 0.0001). This study demonstrates a significant correlation between VEGF-A, VEGF-C, and VEGF-D and no difference in pre-eclamptic and normotensive pregnant women stratified by HIV status suggesting some neutralization of the immune response in HIV-associated pre-eclampsia.

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Citations

Jul 26, 2019·Current Hypertension Reports·Sayuri PadayacheeThajasvarie Naicker
Oct 9, 2018·American Journal of Reproductive Immunology : AJRI·Emeir M McSorleyJ J Strain
Aug 2, 2019·International Journal of Molecular Sciences·Thajasvarie NaickerJagidesa Moodley

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