Effect of vasoactive intestinal polypeptide (VIP) on the in vitro and in vivo motility of the rabbit reproductive tract

Fertility and Sterility
C M Fredericks, S H Ashton


Isolated segments of rabbit ampulla and isthmus and strips of uterus and cervix were spontaneously mechanically active in vitro, and this activity was inhibited in a dose-dependent manner by 2 to 200 ng/ml vasoactive intestinal polypeptide (VIP). The oviductal segments were the most inhibited, the uterine strips the least inhibited. These tissues were stimulated to contract in a dose-dependent manner by epinephrine (EPI), with the uterus and cervix being the more responsive. VIP (200 ng/ml) produced only a slight noncompetitive antagonism of this stimulation. Recordings made with miniature force transducers showed the isthmus, uterus, and cervix also to be spontaneously active in vivo. This activity was inhibited by injections (1, 10, and 20 micrograms) and infusions (1.0 and 2.5 micrograms/min) of VIP. The isthmus was the most inhibited, the cervix the least inhibited. Possible physiologic implications of these pharmacologic effects are discussed.


Jan 1, 1988·Annals of the New York Academy of Sciences·J FahrenkrugC Palle
Oct 15, 1989·The Journal of Comparative Neurology·J R Keast, W C de Groat
Nov 5, 1997·Annals of the New York Academy of Sciences·M L Casey, P C MacDonald

Related Concepts

Dose-Response Relationship, Drug
Enteric Hormones
Accessory Sex Organs, Female
Intravenous Injections
Smooth Muscle
Chinchilla Rabbits
Vasoactive Intestinal Peptide
In Vitro [Publication Type]

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.