Effect of vasopressin blockade on blood pressure regulation during hemorrhage in conscious dogs

Endocrinology
J Schwartz, I A Reid

Abstract

The role of vasopressin in the regulation of blood pressure during nonhypotensive hemorrhage was assessed in conscious dogs. An antagonist of the vasoconstrictor activity of vasopressin was administered (10 microgram/kg) to four normal dogs five min prior to the commencement of a 15 min arterial hemorrhage (1 ml/kg/min). The withdrawn blood was reinfused 15 min after completion of the hemorrhage. In the absence of vasopressin blockade, blood pressure and heart rate did not change significantly, while plasma renin activity increased from 3.8 +/- 0.9 to 10.8 +/- 3.1 ng/ml/3h (P less than 0.005), and plasma corticosteroid concentration increased from 1.5 +/- 0.8 to 8.6 +/- 2.0 microgram/dl (P less than 0.001). Following vasopressin blockade, the same hemorrhage decreased mean arterial pressure from 96 +/- 264 +/- 7 mmHg (P less than 0.001), increased heart rate from 71 +/- 10 to 130 +/- 23 beats/min (P less than 0.05), increased plasma renin activity from 7.1 +/- 0.8 to 30.3 +/- 6.7 ng/ml/3h (P less than 0.005) and increased plasma corticosteroid concentration from 1.9 +/- 0.7 to 11.4 +/- 1.2 microgram/dl (P less than 0.001). These data indicate that vasopressin plays an important role in blood pressure regulation during mild hemo...Continue Reading

Citations

Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·G FeuersteinI J Kopin
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·L F Obika
Dec 11, 2007·Intensive Care Medicine·Matthias LangeMartin Westphal
Jul 1, 1980·Journal of Biochemical and Biophysical Methods·C M Grisham
Sep 1, 2001·The New England Journal of Medicine·D W Landry, J A Oliver
Sep 1, 1995·British Poultry Science·B RobinzonP A Marks
Nov 8, 2003·Critical Care Medicine·James A Russell
Jun 10, 2004·Critical Care Medicine·Mary-Beth MalayDonald W Landry
Sep 9, 2005·Critical Care Medicine·Jacques AlbanèseClaude Martin
Jun 1, 1992·British Journal of Pharmacology·L GariépyP du Souich
Sep 1, 1986·The Journal of Clinical Investigation·L ArnoldaC I Johnston
Nov 20, 2003·Critical Care : the Official Journal of the Critical Care Forum·Cheryl L HolmesJohn T Granton
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Anne DelmasClaude Martin
Mar 13, 2015·Iranian Red Crescent Medical Journal·Seyed Seifollah Beladi Mousavi, Mohamad Reza Tamadon
Feb 24, 2006·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Anette C KrismerVolker Wenzel
Dec 17, 2010·World Journal of Surgery·Stephen M CohnJoel E Michalek
Mar 2, 2002·Anesthesiology·Bhavesh M PatelKeith R Walley
Aug 1, 1995·Clinical and Experimental Hypertension : CHE·J B FregonezeH C Salgado
Jun 2, 1998·Clinical and Experimental Hypertension : CHE·N Japundzic-Zigon
Nov 17, 2012·The Surgical Clinics of North America·Leslie KobayashiRaul Coimbra
Sep 1, 1983·Kidney International·M S Paller, S L Linas
May 1, 1987·Baillière's Clinical Endocrinology and Metabolism·E A Espiner
May 1, 1988·The Journal of Surgical Research·J M BoorsteinJ L Cronenwett
Jul 1, 1987·The Journal of Surgical Research·E J DeMariaD S Gann
Dec 1, 1986·Annals of Emergency Medicine·P D Woolf
Mar 21, 2003·The Annals of Thoracic Surgery·David L S MoralesMehmet C Oz
Aug 1, 1983·American Journal of Obstetrics and Gynecology·R T KellyM Morris
Dec 1, 1986·The Journal of Surgical Research·J L CronenwettJ N Sheagren

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