Effect of venous drainage site on insulin action after simultaneous pancreas-kidney transplantation

Transplantation
Palmina PetruzzoXavier Martin

Abstract

The aim of the present study was to determine the influence of the venous drainage site on insulin homeostasis in simultaneous pancreas-kidney (SPK) transplant recipients. The study included 12 SPK patients with portal venous drainage (P) and 11 SPK patients with systemic venous drainage (S) of pancreas allograft. All of the participants presented similar characteristics. The euglycemic hyperinsulinemic clamp was performed using a 0.4-mU/kg/min insulin infusion. An infusion of [6,6-(2)H2] glucose was used to determine glucose turnover at the basal state and during the clamp to determine liver and peripheral tissue sensitivity to insulin. Minor changes in glycemia and insulinemia were shown: fasting plasma glucose was significantly higher in the SPK-P group and insulinemia was higher in the SPK-S group. Hepatic glucose production was similar in both groups. During the clamp, insulin levels were higher in SPK-S recipients, but hepatic glucose production was suppressed in both groups. Glucose use was lower in SPK-S recipients than in SPK-P recipients, 3.32 +/-1.41 mg/kg/min and 4.70 +/-1.64 mg/kg/min, respectively (P<0.02). Basal and under-clamp free fatty acid levels were similar. In addition, no significant difference in cholest...Continue Reading

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Citations

Jul 18, 2008·Current Diabetes Reports·Elizabeth Diakoff
Oct 25, 2006·Transplantation·Martin L MaiThomas Gonwa
Jul 26, 2012·Current Diabetes Reports·Ugo BoggiGabriella Amorese
Apr 2, 2009·Current Opinion in Organ Transplantation·Carlton J Young
Dec 17, 2009·Current Opinion in Organ Transplantation·Ugo BoggiPiero Marchetti
Sep 27, 2014·Expert Opinion on Drug Metabolism & Toxicology·Erika B Rangel
Sep 18, 2012·Expert Opinion on Drug Metabolism & Toxicology·Erika B Rangel
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nicolas DemartinesPierre-Alain Clavien
Jun 9, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·P PetruzzoM Laville
Jul 14, 2010·ANZ Journal of Surgery·Vincent W T LamRichard D M Allen
Feb 13, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G GuerraH-U Meier-Kriesche
Mar 1, 2006·Transplantation Proceedings·M I BakJ Szmidt
Jul 14, 2017·Clinical Diabetes and Endocrinology·Marcio W Lauria, Antonio Ribeiro-Oliveira
Jul 5, 2005·Annales de chirurgie·P BucherP Morel
Jul 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ugo BoggiThierry Berney

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