Effect of venous oxygenation on arterial desaturation rate during repetitive apneas in lambs

Respiration Physiology
M H WilkinsonV Brodecky

Abstract

While arterial oxygen desaturation during apnea is a common occurrence in adults and infants, the factors determining the rate of desaturation are poorly understood. We describe a theoretical model which suggests that arterial desaturation during an apneic episode occurs in two stages. In the initial stage (stage 1) the oxygen store in the lung is depleted, while in the second phase of the desaturation process (stage 2) tissue oxygen needs are met predominantly by depletion of the blood store. Our model predicts that preapneic venous oxygenation (SvO2) will strongly influence the rate of the desaturation in stage 1 but not in stage 2. We therefore examined the effect of changing preapneic SvO2 on the rate of arterial oxygen desaturation (SaO2) during stage 1 and stage 2 apnea in anaesthetised 10-20 day-old lambs. Preapneic arterial oxygen saturation was maintained constant. In agreement with the model's prediction there were two stages to the desaturation process and during stage 1 a significant increase in SaO2 was observed when preapneic SvO2 was lowered; SaO2 was -3.1 +/- 0.4%.sec-1 when SvO2 = 47.4 +/- 2.1% increasing to -5.8 +/- 0.7%.sec-1 when SvO2 = 28.3 +/- 1.2%. During stage 2, SaO2 was -1.62 +/- 0.07%.sec-1 and was in...Continue Reading

References

Jan 1, 1992·Biology of the Neonate·A BairamP Vert
Jul 1, 1991·Early Human Development·C F Poets, D P Southall
Dec 14, 1985·Lancet·M Partinen, H Palomäki
Mar 1, 1986·The Journal of Pediatrics·J Y MokH Levison
Jan 1, 1982·The Journal of Pediatrics·R T BrouilletteC E Hunt

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Citations

Jul 1, 1996·Respiration Physiology·M H WilkinsonC Jones
Nov 5, 1999·The Journal of Pediatrics·C F Poets
Apr 9, 2011·Journal of Applied Physiology·Shamim NematiJames P Butler
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·Scott A SandsPhilip J Berger
Feb 15, 2011·Patient Safety in Surgery·Lawrence A Lynn, J Paul Curry
Dec 10, 2009·PLoS Computational Biology·Scott A SandsPhilip J Berger
Aug 15, 1997·The Journal of Physiology·D A GrantM H Wilkinson
Apr 14, 2010·Respiratory Physiology & Neurobiology·Scott A SandsPhilip J Berger
Jul 21, 2009·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Oct 1, 2008·Respiratory Physiology & Neurobiology·Bradley A EdwardsPhilip J Berger
Oct 13, 2007·European Journal of Radiology·Nicolau BeckmannAlexandre Trifilieff
Aug 29, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Reginald F Baugh
Dec 8, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Katarzyna CieślarYannick Crémillieux
Apr 25, 2007·NMR in Biomedicine·Katarzyna CieślarYannick Crémillieux
Mar 18, 2005·Journal of Applied Physiology·Paul C JohnsonMarcos Intaglietta
Aug 9, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Nosrat M RaziParesh B Pandit
Feb 28, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Nana WangJing Xu
Jan 1, 2015·Journal of Applied Physiology·Mary A MohrJohn B Delos
Jul 25, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hugh M SmithBhargavi Gali

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