Effect of ventricular stretch on contractile strength, calcium transient, and cAMP in intact canine hearts

The American Journal of Physiology
K TodakaD Burkhoff

Abstract

Isovolumic contractions were imposed by intraventricular balloon in 39 isolated, blood-perfused canine hearts to investigate the effects of myocardial stretch on contractile force. After stabilization at 37 degrees C, left ventricular volume was increased so that end-diastolic pressure increased from 0 to 5 mmHg. After the immediate increase in developed pressure [DP; from 37 +/- 14 to 82 +/- 22 mmHg (means +/- SD)], there was a slow secondary rise in DP (97 +/- 27 mmHg) that peaked at 3 min. However, DP subsequently decreased over the next 7 min back to the initial value (84 +/- 25 mmHg). Light emission from microinjected aequorin (n = 10 hearts) showed that changes in intracellular calcium [3 min: 124 +/- 15% (P < 0.01); 10 min: 99 +/- 18% of baseline] paralleled DP changes. Increases in myocardial adenosine 3',5'-cyclic monophosphate (cAMP) content (n = 12) accompanied the secondary rise in DP. In contrast, the gradual elevation of DP after the stretch was not exerted during continuous beta-adrenergic stimulation by isoproterenol. Thus, in contrast to isolated muscle, stretch only transiently increases intracellular calcium and contractile strength in intact hearts. The findings of changes in cAMP and abolition of the phenom...Continue Reading

References

Apr 1, 1975·Analytical Biochemistry·R W FarmerD H Brown
Mar 1, 1978·Circulation Research·A WalstonJ C Greenfield
Aug 1, 1992·Pflügers Archiv : European journal of physiology·J C KentishP Largen
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P A Watson
Sep 1, 1989·Circulation Research·X P XenophontosH E Morgan
Jun 1, 1989·The American Journal of Physiology·P A WatsonH E Morgan
Jul 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P Cohen
Sep 1, 1985·Journal of Molecular and Cellular Cardiology·D G Allen, J C Kentish
May 1, 1973·The American Journal of Physiology·W W Parmley, L Chuck
Jan 1, 1984·Circulation·D L BrutsaertS U Sys
Nov 1, 1982·Pflügers Archiv : European journal of physiology·J Singh
Jan 1, 1983·Physiological Reviews·E O Feigl
Jul 1, 1984·Circulation Research·P J TucciM C Ribeiro
Mar 1, 1994·Experimental Physiology·M J LabW A Seed
Jun 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Iyengar
Jul 1, 1993·Journal of Applied Physiology·T MiuraK L Peterson
Jul 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P A WatsonA M Kempinski

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Citations

Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P J TucciO Santana
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Juichiro ShimizuDaniel Burkhoff
Dec 19, 2018·The Journal of Physiological Sciences : JPS·Oleg Lookin, Yuri Protsenko
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A C NicolosiZ J Bosnjak
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Regis R LambertsNico Westerhof
Jan 8, 2019·Acta Physiologica·Jarrah M DowrickMarie-Louise Ward
Jan 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Guy A MacGowanSanjeev G Shroff
Aug 18, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Alfred C NicolosiZeljko J Bosnjak
Aug 27, 2021·Frontiers in Cardiovascular Medicine·Daniel TurnerRajan Sah
Jan 5, 2011·Archives of Biochemistry and Biophysics·Irina V KravchenkoVladimir O Popov

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