PMID: 6106879Oct 1, 1980Paper

Effect of ventromedial hypothalamic lesions on the secretion of somatostatin, insulin, and glucagon by the perfused rat pancreas

Metabolism: Clinical and Experimental
Y GotoL A Frohman

Abstract

Somatostatin, insulin, and glucagon secretion by the perfused pancreas were studied in adult female rats 10 days after ventromedial hypothalamic (VMH) lesions and in sham operated controls to assess the role of their hypothalamic control. Insulin secretion was significantly greater in VMH-lesioned rats both under basal conditions and after stimulation by theophylline and arginine plus theophylline. Basal glucagon secretion was greater in VMH-lesioned rats as was the glucagon response to theophylline alone and in combination with arginine. Basal somatostatin secretion with similar in VMH and control rats but somatostatin secretion induced by theophylline and by arginine plus theophylline was significantly increased in VMH-lesioned rats. Both the pancreatic content and concentration of somatostatin were increased in VMH-lesioned rats. These results indicate the presence of hyperresponsiveness of A, B, and D cells following VMH destruction and provide new evidence for a role of the hypothalamus in the regulation of pancreatic somatostatin secretion.

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Citations

Apr 1, 1988·Diabetologia·F Rohner-Jeanrenaud, B Jeanrenaud
Oct 1, 1983·Journal of the Autonomic Nervous System·P H Smith, B J Davis
Dec 1, 1983·Brain Research Bulletin·K T BorerA I Vinik
Nov 1, 1984·Brain Research Bulletin·J H MoltzC P Fawcett
Mar 10, 2017·Physiological Reviews·T D MüllerM H Tschöp
Jan 1, 1982·Annals of the New York Academy of Sciences·M Berelowitz, L A Frohman
Mar 12, 2016·Experimental & Molecular Medicine·Pia V RöderWeiping Han
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·V Schusdziarra, R Schmid
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Alexandra Alvarsson, Sarah A Stanley
Nov 7, 2017·Annals of the New York Academy of Sciences·Kavya Devarakonda, Sarah Stanley
Jan 1, 1982·Acta Neuropathologica·D R GarrisG C Gerritsen
May 1, 1988·Metabolism: Clinical and Experimental·J K StewartC J Goodner

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