PMID: 3760391Nov 1, 1986Paper

Effect of verapamil on infarct size in dogs subjected to coronary artery occlusion with transient reperfusion

Journal of the American College of Cardiology
C A CampbellE Braunwald

Abstract

Reocclusion after successful coronary reperfusion occurs in 15 to 35% of patients receiving thrombolytic therapy for acute myocardial infarction. The present study was designed to simulate the clinical situation of reocclusion and determine whether verapamil might be effective in reducing myocardial necrosis and preserving high energy phosphates in this setting. Pentobarbital-anesthetized, open chest dogs underwent occlusion of the left anterior descending coronary artery for 2 hours followed by 1 hour of reperfusion and a further 4 hours of coronary artery occlusion. Treatment with verapamil (intravenous bolus dose of 0.2 mg/kg body weight followed by infusion of 0.56 +/- 0.14 mg/kg per h) was begun 1 hour after occlusion and infusion was continued for the remainder of the experiment. The dose of verapamil was adjusted to lower mean arterial pressure to approximately 90 mm Hg. The area at risk was determined by intraatrial injection of monastral blue dye and the area of necrosis was assessed by triphenyltetrazolium chloride staining. In vivo myocardial needle biopsy for determination of adenosine triphosphate and creatine phosphate was performed at the end of the experiment. The area of the left ventricle at risk was similar i...Continue Reading

References

Jun 2, 1983·The New England Journal of Medicine·J L AndersonA D Hagan
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Citations

Nov 28, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Gerald S WernerHans R Figulla
Dec 1, 1991·Catheterization and Cardiovascular Diagnosis·R ClugstonR A Kloner
Mar 1, 1988·Journal of the American College of Cardiology·K Przyklenk, R A Kloner
Dec 1, 1988·Journal of the American College of Cardiology·E Braunwald
Oct 1, 1987·Journal of the American College of Cardiology·D Garcia-DoradoM Galinanes
Sep 19, 1998·Journal of the American College of Cardiology·P ThérouxM Juneau
Jun 9, 2016·Bulletin of Experimental Biology and Medicine·Yu B LishmanovA V Mukhomedzyanov
Mar 1, 1990·Clinical Cardiology·M C Fishbein

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