Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats

Journal of Cardiovascular Pharmacology
Murugesan Saravanakumar, Boobalan Raja

Abstract

Hypertension is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. This study was undertaken to investigate the effects of veratric acid (VA) on blood pressure, plasma, and tissue lipid profile in N-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. Hypertension was induced in adult male albino rats of Wistar strain, weighing 180-220 g, by oral administration of L-NAME (40 mg/kg) in drinking water for 4 weeks. Rats were treated with VA (40 mg/kg) for 4 weeks. L-NAME-treated rats showed significant increase in mean arterial pressure and heart rate. A significant increase in the concentrations of plasma, tissue (liver and kidney) lipids, and lipoproteins and a significant decrease in the concentration of high-density lipoprotein cholesterol were noticed in L-NAME-induced hypertensive rats. The activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase increased significantly in the liver and kidney, whereas the activities of lipoprotein lipase and lecithin cholesterol acyl transferase were decreased significantly in the plasma of hypertensive rats. Histopathology of liver and kidney and in vitro study also confirmed the biochemical findings of this study. T...Continue Reading

References

Jul 1, 1992·Acta Physiologica Scandinavica·S Moncada
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Jun 1, 1990·Circulation Research·M Kelm, J Schrader
Nov 1, 1990·Circulation·M Akhtar
Jul 1, 1989·Circulation·P M Vanhoutte, H Shimokawa
Jun 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·K FalholtW Falholt
Sep 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J HitzG Siest
May 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A J CayatteR A Cohen
Feb 1, 1993·Seminars in Liver Disease·R S McCuskey, F D Reilly
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Oct 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Y M Dambisya, T L Lee
May 1, 1997·Clinical and Experimental Pharmacology & Physiology·H Moreno JúniorG de Nucci
May 16, 1998·The Journal of Clinical Investigation·H M KwonA Lerman
Mar 24, 2000·BMJ : British Medical Journal·M Law
Sep 6, 2000·Kidney International·R J Schmidt, C Baylis
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Diana M AttiaJaap A Joles
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Pirjo Mattila, Jorma Kumpulainen
Jan 23, 2003·Nutrition Journal·Sanjay K Banerjee, Subir K Maulik
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitomo MoriTadaaki Iwasaki
Nov 15, 2007·Nitric Oxide : Biology and Chemistry·Alexander HoetzelBenedikt H J Pannen
Jun 13, 2008·Chemico-biological Interactions·Tuba Ak, Ilhami Gülçin
Jul 4, 2008·European Journal of Medicinal Chemistry·Balasubramanian NarasimhanRakesh Narang
Oct 22, 2008·Chemico-biological Interactions·Ilhami Gülçin
Sep 23, 2011·European Journal of Pharmacology·Murugesan Saravanakumar, Boobalan Raja

❮ Previous
Next ❯

Citations

Jun 12, 2013·Journal of Chromatographic Science·Ming YuanZhen-Xiao Sun
Oct 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fidèle NtchapdaDimo Théophile
Mar 23, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mireille Flaure Metchi DonfackThéophile Dimo
Mar 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esther Oluwasola AlukoAdesoji Adedipe Fasanmade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.