Effect of Vernonia cognata on oxidative damage induced by ethanol in rats

Human & Experimental Toxicology
C S MotaL F Bauermann

Abstract

Free radicals production and oxidative stress play a central role in injuries caused by ethanol (EtOH) on gastric mucosal. Thus, strategies to counteract EtOH toxicity are highly desirable. This study was aimed at evaluating whether Vernonia cognata extract would reduce EtOH effects in rats. Rats received Vernonia cognata extract (0, 1 and 2 g/kg bw, by gavage) 1 hour after EtOH had been administered (0 or 70%, 0.5 mL/100 g bw, by gavage) and were killed 1 hour after Vernonia cognata extract administration. The stomach was removed for macroscopic and histopathological evaluation, as well as, oxidative stress markers such as lipoperoxidation (LPO) and non-protein thiol groups (NPSH) levels and catalase (CAT) activity. EtOH acute exposure increased LPO and decreased NPSH levels and CAT activity along with macroscopic and microscopic lesions in gastric tissue, confirming the involvement of oxidative stress in EtOH toxicity. Vernonia cognata extract attenuated oxidative and histopathological features induced by EtOH at all evaluated doses. Moreover, both studied doses of Vernonia cognata extract caused an increase in NPSH levels per se. However, only the dose of 2 g/kg reverted all macroscopic changes caused by EtOH toxicity. The p...Continue Reading

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Citations

Jul 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robson Borba de FreitasMargareth Linde Athayde
Feb 12, 2013·Journal of Ethnopharmacology·Ngeh J Toyang, Rob Verpoorte
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Aline Augusti BoligonLiliane de Freitas Bauermann
Jul 18, 2018·Dose-response : a Publication of International Hormesis Society·Modinat A AdefisayoKehinde P Olamilosoye
Sep 12, 2015·Human & Experimental Toxicology·B T RovaniL de Freitas Bauermann
Sep 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdelsamed I ElshamyMohamed A Farag
Dec 10, 2020·Food Research International·Dariane Trivisiol da SilvaTatiana Emanuelli

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